PMID- 573768
OWN - NLM
STAT- MEDLINE
DCOM- 19791220
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 1
IP  - 2
DP  - 1978 Apr
TI  - Klinefelter's syndrome: a study of its hormonal plasma pattern.
PG  - 149-54
AB  - Plasma testosterone (T), dihydrotestosterone (DHT), 17 beta-estradiol (E2), 
      17-hydroxyprogesterone (17-OHP), androstenedione (delta), dehydroepiandrosterone 
      (DHEA), dehydroepiandrosterone sulphate (DHEAS), 5-androstene-3 beta-17 beta-diol 
      (A-diol) and cortisol (F) have been measured in a group of normal males and in a 
      group of patients with Klinefelter's syndrome (KS) before and after hCG 
      stimulation. Significantly lower baseline levels of T and DHT and significantly 
      higher baseline levels of E2 were found in patients with KS. No significant 
      differences were found between baseline levels of 17-OHP, delta, DHEA, DHEAS, 
      A-diol, and F. After hCG stimulation between T, DHT, E2 and 17-OHP levels showed 
      a significant increase in the two groups of subjects. The percentage variation of 
      T and DHT, however, was much less important in Klinefeiter patients, while E2 and 
      17-OHP did not show a significantly different pattern from that of normal 
      controls, hCG administration did not produce any significant variation of delta, 
      DHEA, DHEAS, and F in the two groups of subjects, while A-diol levels increased 
      significantly in normal subjects, but not in Klinefelter patients. Our data may 
      be consistent with the hypothesis that testicular steroidogenesis in Klinefelter 
      patients is impaired below the 21-C-steriod level not only at delta 4 but also at 
      the delta 5 pathway.
FAU - Forti, G
AU  - Forti G
FAU - Giusti, G
AU  - Giusti G
FAU - Borghi, A
AU  - Borghi A
FAU - Pazzagli, M
AU  - Pazzagli M
FAU - Fiorelli, G
AU  - Fiorelli G
FAU - Cabresi, E
AU  - Cabresi E
FAU - Mannelli, M
AU  - Mannelli M
FAU - Bassi, F
AU  - Bassi F
FAU - Giannotti, P
AU  - Giannotti P
FAU - Fusi, S
AU  - Fusi S
FAU - Serio, M
AU  - Serio M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Androgens)
RN  - 0 (Androstenediols)
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Estrogens)
RN  - 0 (Hydroxyprogesterones)
RN  - 0 (Progestins)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Androgens/*blood
MH  - Androstenediols/blood
MH  - Animals
MH  - Chorionic Gonadotropin/administration & dosage
MH  - Dihydrotestosterone/blood
MH  - Dogs
MH  - Estradiol/blood
MH  - Estrogens/*blood
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Hydroxyprogesterones/blood
MH  - Klinefelter Syndrome/*blood
MH  - Male
MH  - Progestins/*blood
MH  - Testosterone/blood
EDAT- 1978/04/01 00:00
MHDA- 1978/04/01 00:01
CRDT- 1978/04/01 00:00
PHST- 1978/04/01 00:00 [pubmed]
PHST- 1978/04/01 00:01 [medline]
PHST- 1978/04/01 00:00 [entrez]
AID - 10.1007/BF03350363 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1978 Apr;1(2):149-54. doi: 10.1007/BF03350363.