PMID- 574418
OWN - NLM
STAT- MEDLINE
DCOM- 19800226
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 179
IP  - 2
DP  - 1979 Dec 28
TI  - Ontogeny of catecholamine turnover rates in limbic and hypothalamic structures in 
      relation to serum prolactin and gonadotropin levels.
PG  - 281-93
AB  - Norepinephrine (NE) and dopamine (DA) concentrations and turnover rates have been 
      studied in the n. accumbens, medial preoptic area (MPO) and anterior and 
      posterior parts of the mediobasal hypothalamus of developing rats. Turnover rates 
      are determined by injection of alpha-methyl-p-tyrosine 30 and 90 min prior to 
      decapitation. NE concentrations and turnover in the n. accumbens were low in all 
      age groups with slightly increased values between days 20 and 35 after birth 
      whereas DA concentrations and turnover rates were low at day 15 and 20 and at 
      high adult values by day 25 after birth. Medial preoptic and anterior mediobasal 
      hypothalamic catecholamines exhibited a rather unique pattern. Concentrations and 
      turnover rates were low in 15-day-old animals and increased between days 20 and 
      30 to very high values. Such high values were never observed in adult diestrous 
      animals. The same pattern was also observed in the posterior mediobasal 
      hypothalamus for NE concentrations and turnover rates whereas the respective 
      values for DA showed relatively large fluctuations. On the basis of catecholamine 
      measurements 30 and 90 min after blockade of tyrosine hydroxylase an attempt was 
      also made to differentiate turnover rates of the functional and of the storage 
      pool. Serum LH levels in the 15-day-old animals showed large fluctuations. FSH 
      levels were high and prolactin levels were low. At the time of increased preoptic 
      and hypothalamic NE and DA turnover rates, serum prolactin levels were also high 
      whereas serum LH levels were lowest between days 20 and 30 and then slightly 
      increased. Serum FSH levels were uniformly low. The possibility is discussed that 
      high NE turnover may stimulate pituitary LH and prolactin release by hypothalamic 
      mechanisms. Hihgh serum prolactin levels may stimulate DA turnover which is 
      inhibitory to pituitary LH release, thus counteracting the stimulatory effect of 
      NE on LH-RH release. The dopaminergic inhibition of LH may be relieved at the 
      time of puberty partially because the DA receptors become desensitized to the 
      action of DA.
FAU - Hohn, K G
AU  - Hohn KG
FAU - Wuttke, W
AU  - Wuttke W
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Methyltyrosines)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Diestrus
MH  - Dopamine/*metabolism
MH  - Female
MH  - Follicle Stimulating Hormone/*blood
MH  - Hypothalamus/*metabolism
MH  - Hypothalamus, Middle/drug effects/metabolism
MH  - Limbic System/*metabolism
MH  - Luteinizing Hormone/*blood
MH  - Methyltyrosines/pharmacology
MH  - Norepinephrine/*metabolism
MH  - Nucleus Accumbens/metabolism
MH  - Pregnancy
MH  - Preoptic Area/metabolism
MH  - Prolactin/*blood
MH  - Rats
EDAT- 1979/12/28 00:00
MHDA- 1979/12/28 00:01
CRDT- 1979/12/28 00:00
PHST- 1979/12/28 00:00 [pubmed]
PHST- 1979/12/28 00:01 [medline]
PHST- 1979/12/28 00:00 [entrez]
AID - 0006-8993(79)90444-X [pii]
AID - 10.1016/0006-8993(79)90444-x [doi]
PST - ppublish
SO  - Brain Res. 1979 Dec 28;179(2):281-93. doi: 10.1016/0006-8993(79)90444-x.