PMID- 590224
OWN - NLM
STAT- MEDLINE
DCOM- 19780218
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 18
IP  - 4
DP  - 1977 Dec
TI  - Comparison of effects of bicuculline, strychnine, and picrotoxin with those of 
      pentylenetetrazol on photically evoked afterdischarges.
PG  - 465-70
AB  - The effects of bicuculline, strychnine, and picrotoxin on photically evoked 
      afterdischarges (PhADs) in rat visual cortex were compared with those of 
      pentylenetetrazol (a known PhAD potentiator) and a diazepam (a known PhAD 
      suppressor) challenge. Bicuculline was found to augment PhADs in a manner similar 
      to that found with pentylenetetrazol, with the exception that potentiation only 
      occurred at convulsive levels whereas pentylenetetrazol augmentation occurred at 
      both subconvulsive and convulsive levels. Diazepam suppressed 
      bicuculline-potentiated PhADs. Picrotoxin was found to have some limited 
      augmenting effect on PhAD activity but in a manner unlike that observed with 
      either bicuculline or pentylenetetrazol. Strychnine had no systematic augmenting 
      effect on PhADs. These results were discussed in terms of the possible role of 
      GABA in thalamic systems responsible for PhAD production.
FAU - Bigler, E D
AU  - Bigler ED
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Isoquinolines)
RN  - 124-87-8 (Picrotoxin)
RN  - H9Y79VD43J (Strychnine)
RN  - WM5Z385K7T (Pentylenetetrazole)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Isoquinolines/*pharmacology
MH  - Light
MH  - Pentylenetetrazole/*pharmacology
MH  - Picrotoxin/*pharmacology
MH  - Rats
MH  - Seizures/chemically induced/*physiopathology
MH  - Strychnine/*pharmacology
MH  - Visual Cortex/*drug effects
EDAT- 1977/12/01 00:00
MHDA- 1977/12/01 00:01
CRDT- 1977/12/01 00:00
PHST- 1977/12/01 00:00 [pubmed]
PHST- 1977/12/01 00:01 [medline]
PHST- 1977/12/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1977.tb04993.x [doi]
PST - ppublish
SO  - Epilepsia. 1977 Dec;18(4):465-70. doi: 10.1111/j.1528-1157.1977.tb04993.x.