PMID- 6023777
OWN - NLM
STAT- MEDLINE
DCOM- 19670627
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 46
IP  - 3
DP  - 1967 Mar
TI  - Studies on auditory thresholds in normal man and in patients with adrenal 
      cortical insufficiency: the role of adrenal cortical steroids.
PG  - 429-35
AB  - Auditory thresholds for sinusoidal tones were determined in eight patients with 
      adrenal cortical insufficiency (four with Addison's disease and four with 
      panhypopituitarism) and compared to those in normal volunteers. In adrenal 
      cortical insufficiency (ACI) the auditory detection sensitivity is significantly 
      more acute than that of normal subjects over most of the frequency range, but 
      especially in the region of greatest hearing sensitivity of normal subjects, 
      1,000 to 2,000 cycles per second (cps). Treatment of the patients with 
      deoxycorticosterone acetate decreased serum potassium concentration and produced 
      gains in body weight but did not alter auditory detection thresholds. Treatment 
      with prednisolone or with maintenance doses of carbohydrateactive steroids 
      returned the auditory detection threshold to normal in every patient tested.The 
      mechanism by which carbohydrate-active steroids affect the sensitivity of the 
      nervous system to sound is not known. However, since the senses of taste, smell, 
      and hearing are all affected in similar fashion by their removal and replacement, 
      there appears to be a generalized increase in sensitivity to all sensory stimuli 
      in patients with ACI not receiving steroids. These hormones may play a 
      significant role in maintaining the level of responsiveness of the sensory system 
      to incoming stimuli.
FAU - Henkin, R I
AU  - Henkin RI
FAU - McGlone, R E
AU  - McGlone RE
FAU - Daly, R
AU  - Daly R
FAU - Bartter, F C
AU  - Bartter FC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 40GP35YQ49 (Desoxycorticosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Addison Disease/*physiopathology
MH  - Adolescent
MH  - Adult
MH  - Audiometry
MH  - Desoxycorticosterone/therapeutic use
MH  - Female
MH  - *Hearing
MH  - Humans
MH  - Hypopituitarism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Potassium/blood
MH  - Sodium/blood
PMC - PMC297063
EDAT- 1967/03/01 00:00
MHDA- 1967/03/01 00:01
PMCR- 1967/03/01
CRDT- 1967/03/01 00:00
PHST- 1967/03/01 00:00 [pubmed]
PHST- 1967/03/01 00:01 [medline]
PHST- 1967/03/01 00:00 [entrez]
PHST- 1967/03/01 00:00 [pmc-release]
AID - 10.1172/JCI105544 [doi]
PST - ppublish
SO  - J Clin Invest. 1967 Mar;46(3):429-35. doi: 10.1172/JCI105544.