PMID- 602879
OWN - NLM
STAT- MEDLINE
DCOM- 19780329
LR  - 20190823
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 7
IP  - 5-6
DP  - 1977 Dec
TI  - Administration of anti-inflammatory compounds in silastic capsules.
PG  - 555-62
AB  - Eleven compounds, within hollow capsules of polydimethylsiloxane (Silastic), have 
      been studied with regard to their rate of release and anti-inflammatory activity 
      in the Adjuvant Arthritic (AA) rat. All of the compounds diffused through the 
      capsule wall to some extent with cortisone acetate exhibiting the slowest and 
      ibuprofen the fastest release rate. Of the eleven encapsulated compounds, only 
      phenylbutazone, indomethacin, ibuprofen and naproxen significantly reduced right 
      and left paw volume below that of control value. Silastic encapsulation increases 
      efficacy of phenylbutazone and indomethacin two to three times over subcutaneous 
      or oral administration. Based on potency and duration of constant release, 
      indomethacin and naproxen should exhibit anti-inflammatory activity in excess of 
      12 months.
FAU - Jones, R C
AU  - Jones RC
FAU - Datko, L J
AU  - Datko LJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Capsules)
RN  - 0 (Silicone Elastomers)
RN  - 57Y76R9ATQ (Naproxen)
RN  - GN5P7K3T8S (Phenylbutazone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Arthritis, Experimental/drug therapy
MH  - Capsules
MH  - Indomethacin/administration & dosage
MH  - Injections, Subcutaneous
MH  - Male
MH  - Naproxen/administration & dosage
MH  - Phenylbutazone/administration & dosage
MH  - Rats
MH  - Silicone Elastomers
EDAT- 1977/12/01 00:00
MHDA- 1977/12/01 00:01
CRDT- 1977/12/01 00:00
PHST- 1977/12/01 00:00 [pubmed]
PHST- 1977/12/01 00:01 [medline]
PHST- 1977/12/01 00:00 [entrez]
AID - 10.1007/BF02111129 [doi]
PST - ppublish
SO  - Agents Actions. 1977 Dec;7(5-6):555-62. doi: 10.1007/BF02111129.