PMID- 6087512
OWN - NLM
STAT- MEDLINE
DCOM- 19840914
LR  - 20211216
IS  - 0035-9203 (Print)
IS  - 0035-9203 (Linking)
VI  - 78
IP  - 3
DP  - 1984
TI  - A controlled study of endemic sporadic diarrhoea among adult residents of 
      southern Brazil.
PG  - 363-9
AB  - The aetiology of sporadic summer diarrhoea and enterotoxin (LT) antibody titres 
      was studied among 43 adult patients in southern Brazil who had an acute, 
      untreated diarrhoeal illness and 43 age- and sex-matched controls from the same 
      area. A potential pathogen was identified in 33 of 34 patients and in 17 of 43 
      controls (p less than 0.01). 10 Shigella, one invasive Escherichia coli, one 
      Salmonella and one Entamoeba histolytica were identified in 17 patients with 
      inflammatory diarrhoea (faecal polymorphonuclear neutrophil leucocytes (PMN) 
      present). In the other four only enterotoxigenic strains of E. coli were 
      identified. Among 26 patients with non-inflammatory (no faecal PMN) diarrhoea, 
      heat-stable (ST) toxin-producing coliforms were the most common pathogens 
      isolated (27%). Heat-labile (LT) toxin-producing coliforms or serological rises 
      to LT were seen in five patients, Strongyloides larvae in five, Giardia lamblia 
      trophozoites in four and an LT-producing Salmonella in one. No pathogen was found 
      in 10 patients with non-inflammatory diarrhoea. Among 43 controls, 11 LT 
      coliforms, two Shigella and two Strongyloides larvae were found. 40 of 41 
      controls had detectable serum anti-LT antibody. A single ST-producing E. coli was 
      found in one other control. No pathogen was identified in 26 controls. No 
      rotaviruses or Norwalk-like viral agents were seen by direct or immune electron 
      microscopy of stool filtrates. While LT-producing E. coli are frequently 
      associated with endemic summer childhood diarrhoea in southern Brazil and are 
      recognized causes of travellers' diarrhoea, this study shows that they are often 
      carried asymptomatically by adults living in this region.(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Korzeniowski, O M
AU  - Korzeniowski OM
FAU - Dantas, W
AU  - Dantas W
FAU - Trabulsi, L R
AU  - Trabulsi LR
FAU - Guerrant, R L
AU  - Guerrant RL
LA  - eng
GR  - T32A107046/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (heat stable toxin (E coli))
RN  - D9K3SN2LNY (heat-labile enterotoxin, E coli)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bacterial Toxins/biosynthesis
MH  - Brazil
MH  - Diarrhea/etiology/*microbiology/parasitology
MH  - Entamoeba histolytica/isolation & purification
MH  - Enterotoxins/biosynthesis
MH  - Escherichia coli/isolation & purification/metabolism
MH  - *Escherichia coli Proteins
MH  - Feces/microbiology
MH  - Female
MH  - Giardia/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Salmonella/isolation & purification
MH  - Shigella/isolation & purification
MH  - Strongyloides/isolation & purification
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1016/0035-9203(84)90123-8 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 1984;78(3):363-9. doi: 10.1016/0035-9203(84)90123-8.