PMID- 6093176
OWN - NLM
STAT- MEDLINE
DCOM- 19841212
LR  - 20190913
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 9
IP  - 3
DP  - 1984
TI  - Behavioral effects of progestin in the brain.
PG  - 217-31
AB  - In this article we review research on the role of progestins in the regulation of 
      estrous responsiveness in female rats. Estrous responsiveness normally results 
      from a synergistic action of estradiol (E2) and progesterone (P). E2 primes the 
      system but normally does not result in estrous behavior. The full expression of 
      estrous responsiveness results from the action of P on the E2-primed system. It 
      has been demonstrated with implants of dilute E2 (1 part E2: 250 parts 
      cholesterol) that the site of E2 priming is the ventromedial nucleus of the 
      hypothalamus (VMN). In females primed with systemically administered E2, P also 
      acts on the VMN to facilitate full estrous responsiveness. It has been shown in 
      addition that estrous responsiveness results from sequential application of E2 
      and P to the VMN but not to other areas of the brain. The VMN is also the site at 
      which P produces sequential inhibition of estrous responsiveness. The time course 
      of P action in facilitating full estrous responsiveness is about two hours, 
      regardless of whether the hormone is administered intracerebrally or 
      intravenously. The duration of estrous responsiveness is directly correlated with 
      the length of time P is in contact with brain tissue. Experiments with the 
      protein synthesis inhibitor anisomycin are consistent with the view that P acts 
      in the VMN by way of a protein synthetic mechanism to facilitate estrous 
      behavior; however, other mechanisms must be considered as alternatives. Finally, 
      we address the question of whether estrogenic priming depends upon induction of 
      progestin receptors in the VMN. Results indicate that estrogenic priming of 
      estrous responsiveness may occur without concomitant induction of progestin 
      receptors.
FAU - Barfield, R J
AU  - Barfield RJ
FAU - Glaser, J H
AU  - Glaser JH
FAU - Rubin, B S
AU  - Rubin BS
FAU - Etgen, A M
AU  - Etgen AM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Nerve Tissue Proteins)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - E0399OZS9N (Cyclic AMP)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Animals
MH  - Basal Ganglia/drug effects
MH  - Brain/*drug effects
MH  - Brain Mapping
MH  - Castration
MH  - Cyclic AMP/physiology
MH  - Cyclic GMP/physiology
MH  - Drug Interactions
MH  - Estradiol/pharmacology
MH  - Estrus/*drug effects
MH  - Female
MH  - Mesencephalon/drug effects
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Pregnancy
MH  - Preoptic Area/drug effects
MH  - Progesterone/*pharmacology
MH  - Rats
MH  - Sexual Behavior, Animal/drug effects
MH  - Time Factors
MH  - Ventromedial Hypothalamic Nucleus/drug effects
RF  - 63
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1016/0306-4530(84)90002-7 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 1984;9(3):217-31. doi: 10.1016/0306-4530(84)90002-7.