PMID- 6093365
OWN - NLM
STAT- MEDLINE
DCOM- 19841206
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 138
IP  - 2
DP  - 1984 Oct 30
TI  - The methylation pattern of endogenous mouse mammary tumor virus proviral genes is 
      tissue specific and stably inherited.
PG  - 212-24
AB  - The methylation pattern of mouse mammary tumor virus (MMTV) proviral genes 
      endogenous to the mouse strains C3H, 020, FM/JmsA, C57BL6, and BALB/c were 
      investigated in various organs and mammary tumor tissue. Digestion of DNA with 
      EcoRI or with EcoRI and HpaII followed by Southern blotting analysis and 
      hybridization to a nick-translated MMTV DNA, allowed the distinction between the 
      fully methylated and hypomethylated gene copies. MMTV proviral gene methylation 
      was found to be organ specific, and the methylation pattern is stably inherited. 
      The same proviral units present in different strains of mice exhibit the same 
      organ-specific methylation patterns. Although proviral genes are normally heavily 
      methylated in all tissues, hypomethylation of endogenous proviral genes was found 
      in organs not known to express MMTV.
FAU - Gunzburg, W H
AU  - Gunzburg WH
FAU - Hynes, N E
AU  - Hynes NE
FAU - Groner, B
AU  - Groner B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA, Viral)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Animals
MH  - DNA Restriction Enzymes
MH  - DNA, Viral/*genetics
MH  - *Genes, Viral
MH  - Heart/physiology
MH  - Lung/physiology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - *Methylation
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Tissue Distribution
EDAT- 1984/10/30 00:00
MHDA- 1984/10/30 00:01
CRDT- 1984/10/30 00:00
PHST- 1984/10/30 00:00 [pubmed]
PHST- 1984/10/30 00:01 [medline]
PHST- 1984/10/30 00:00 [entrez]
AID - 10.1016/0042-6822(84)90346-5 [doi]
PST - ppublish
SO  - Virology. 1984 Oct 30;138(2):212-24. doi: 10.1016/0042-6822(84)90346-5.