PMID- 6095309
OWN - NLM
STAT- MEDLINE
DCOM- 19850122
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 81
IP  - 23
DP  - 1984 Dec
TI  - Infection of human endothelial cells by human T-cell leukemia virus type I.
PG  - 7591-5
AB  - The effects of the human T-cell leukemia virus type I (HTLV-I) on cultured human 
      endothelial cells were evaluated. Coculture of endothelial monolayers with either 
      irradiated HTLV-producing lymphocytes or cell-free virus resulted in the 
      production of multinucleated syncytia. The development of syncytia was inhibited 
      by sera from patients with adult T-cell leukemia/lymphoma (ATLL). HTLV antigens 
      were present on endothelial syncytia passaged in culture for greater than 3 
      months as detected by an anti-p19 monoclonal antibody, which detects a core 
      protein of HTLV-I, and by ATLL sera. Moreover, these HTLV-infected endothelial 
      cells were then able to infect and transform normal cord blood T lymphocytes with 
      HTLV. These studies demonstrate that human endothelial cells are susceptible to 
      productive HTLV-I infection in vitro and may have relevance for the spectrum of 
      human disease associated with this family of retroviruses.
FAU - Hoxie, J A
AU  - Hoxie JA
FAU - Matthews, D M
AU  - Matthews DM
FAU - Cines, D B
AU  - Cines DB
LA  - eng
GR  - HL-28220/HL/NHLBI NIH HHS/United States
GR  - K04-HL-00956/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antigens, Viral/analysis
MH  - Cell Transformation, Viral
MH  - Cells, Cultured
MH  - Deltaretrovirus/*pathogenicity
MH  - Endothelium/*microbiology/ultrastructure
MH  - Female
MH  - Humans
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology/microbiology
MH  - Microscopy, Electron
MH  - Pregnancy
MH  - Umbilical Veins/*microbiology
PMC - PMC392193
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
PMCR- 1985/06/01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
PHST- 1985/06/01 00:00 [pmc-release]
AID - 10.1073/pnas.81.23.7591 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1984 Dec;81(23):7591-5. doi: 10.1073/pnas.81.23.7591.