PMID- 6095680
OWN - NLM
STAT- MEDLINE
DCOM- 19850124
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 247
IP  - 6 Pt 1
DP  - 1984 Dec
TI  - Alterations in motor function of the small intestine from intravenous and 
      intraluminal cholecystokinin.
PG  - G724-8
AB  - Cholecystokinin has been found within the lumen of the gastrointestinal tract; 
      however, its effect on intestinal motility has not been studied. We examined the 
      effect of intraluminal and intravenous infusion of the octapeptide of 
      cholecystokinin (CCK-OP) on myoelectric activity in the intestine of rabbits. 
      CCK-OP was infused intraluminally at 1,000 ng X kg-1 X h-1, and portal venous 
      blood samples were obtained hourly for plasma immunoreactive CCK. CCK-OP was also 
      infused intravenously at a similar rate, and hourly peripheral venous blood 
      samples were obtained for plasma immunoreactive CCK. Myoelectric activity was 
      monitored in a 12-cm ligated ileal segment and the proximal adjacent small 
      intestine after the infusion of intraluminal or intravenous CCK-OP. Intraluminal 
      infusion of CCK-OP caused a significant increase (P less than 0.01) in both 
      migrating action potential complexes (MAPC) and repetitive bursts of action 
      potentials (RBAP) (3.1 +/- 0.8 MAPC/h and 4.6 +/- 1.3 RBAP/h). In contrast, 
      intravenous CCK-OP induced only repetitive bursts of action potentials (8.3 +/- 
      1.7 RBAP/h, P less than 0.01). In summary, alterations in intestinal motility may 
      vary according to the route of administration of the individual peptide. 
      Furthermore, results from these studies suggest that intraluminal release of 
      regulatory peptides may be important in the modulation of intestinal motility.
FAU - Sninsky, C A
AU  - Sninsky CA
FAU - Wolfe, M M
AU  - Wolfe MM
FAU - McGuigan, J E
AU  - McGuigan JE
FAU - Mathias, J R
AU  - Mathias JR
LA  - eng
GR  - AA-03965/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 9011-97-6 (Cholecystokinin)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Cholecystokinin/blood
MH  - Gastrointestinal Motility/*drug effects
MH  - Ileum/*drug effects
MH  - Infusions, Parenteral
MH  - Injections
MH  - Rabbits
MH  - Radioimmunoassay
MH  - Sincalide/*pharmacology
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.1152/ajpgi.1984.247.6.G724 [doi]
PST - ppublish
SO  - Am J Physiol. 1984 Dec;247(6 Pt 1):G724-8. doi: 10.1152/ajpgi.1984.247.6.G724.