PMID- 6096637
OWN - NLM
STAT- MEDLINE
DCOM- 19850211
LR  - 20190825
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 8
IP  - 6
DP  - 1984
TI  - Differential methylation of class I histocompatibility antigen genes in T-cell 
      lines derived from two different types of T-cell malignancies.
PG  - 965-73
AB  - We have previously shown that two human T-cell lines (HSB and 8402) derived from 
      patients with childhood T-cell ALL (T-ALL) do not synthesize detectable mRNA for 
      HLA-DR alpha. The DR alpha genes in both cell lines are hypermethylated relative 
      to the same genes in T-cell lines infected with human T-cell leukemia virus 
      (HTLV) and derived from patients with adult T-cell leukemia/lymphoma (ATL). These 
      latter cell lines do express HLA-DR alpha-mRNA, as well as HLA-DR surface 
      antigens. We report here that the genes for HLA class I antigens are also highly 
      methylated in the T-ALL T-cell lines relative to the same genes in the ATL T-cell 
      lines, normal peripheral blood T cells, and autologous normal B-cell lines. In 
      spite of substantial differences in the extent of methylation of class I-related 
      genes, no obvious differences exist among these cell types in their levels of 
      expression of HLA-A and -B antigens. The data clearly indicate, however, that the 
      class I and class II components of the major histocompatibility complex are 
      unusually hypermethylated in several T-ALL-derived cell lines, while ATL T-cell 
      lines do not substantially differ in this respect from normal peripheral blood 
      T-cells.
FAU - Clarke, M F
AU  - Clarke MF
FAU - Mann, D L
AU  - Mann DL
FAU - Murray, C
AU  - Murray C
FAU - Reitz, M S
AU  - Reitz MS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (DNA, Neoplasm)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Acute Disease
MH  - Cell Line
MH  - DNA, Neoplasm/*metabolism
MH  - Deltaretrovirus
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Leukemia/*immunology
MH  - Lymphoma/immunology
MH  - Methylation
MH  - RNA, Messenger/analysis
MH  - *T-Lymphocytes
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1016/0145-2126(84)90050-x [doi]
PST - ppublish
SO  - Leuk Res. 1984;8(6):965-73. doi: 10.1016/0145-2126(84)90050-x.