PMID- 6098052
OWN - NLM
STAT- MEDLINE
DCOM- 19850314
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 144
IP  - 3
DP  - 1984 Nov
TI  - Photodynamic inactivation of bladder cancer cells (MGH-U1) sensitized with 
      acridine orange and irradiated by argon laser.
PG  - 265-71
AB  - Photodynamic inactivation of bladder cancer cells (MGH-U1) was investigated in 
      order to apply laser therapy to the treatment of bladder cancer. After stained 
      with acridine orange (AO), the material cells were irradiated with argon laser. 
      After 24 hr incubation the survival was counted with a hemocytometer. The number 
      of stained cells showed a less than 5% decrease and the number of irradiated (for 
      15 min) unstained cells showed no decrease compared with untreated cells. 
      Participation of singlet oxygen process in inactivation of MGH-U1 cells was 
      confirmed by the use of D2O and NaN3. The result shows that argon laser at the 
      low intensity and with short irradiation time has a sufficient cytocydal effect, 
      suggesting the usefulness of photodynamic inactivation of argon laser with 
      topical use of acridine orange in the treatment of bladder cancer.
FAU - Ishikawa, S
AU  - Ishikawa S
FAU - Nemoto, R
AU  - Nemoto R
FAU - Kanoh, S
AU  - Kanoh S
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Ishizaka, S
AU  - Ishizaka S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 059QF0KO0R (Water)
RN  - AR09D82C7G (Deuterium)
RN  - F30N4O6XVV (Acridine Orange)
RN  - J65BV539M3 (Deuterium Oxide)
SB  - IM
MH  - Acridine Orange/therapeutic use
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Deuterium/pharmacology
MH  - Deuterium Oxide
MH  - Humans
MH  - Laser Therapy
MH  - *Photochemotherapy
MH  - Time Factors
MH  - Urinary Bladder Neoplasms/*therapy
MH  - Water/pharmacology
EDAT- 1984/11/01 00:00
MHDA- 1984/11/01 00:01
CRDT- 1984/11/01 00:00
PHST- 1984/11/01 00:00 [pubmed]
PHST- 1984/11/01 00:01 [medline]
PHST- 1984/11/01 00:00 [entrez]
AID - 10.1620/tjem.144.265 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 1984 Nov;144(3):265-71. doi: 10.1620/tjem.144.265.