PMID- 6098329
OWN - NLM
STAT- MEDLINE
DCOM- 19850416
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 323
IP  - 1
DP  - 1984 Dec 3
TI  - Evidence that naloxonazine produces prolonged antagonism of central delta opioid 
      receptor activity in vivo.
PG  - 123-7
AB  - Intracerebroventricular (i.c.v.) administrations of the postulated mu 1 opioid 
      receptor antagonist naloxonazine produced an increase in the frequency of urinary 
      bladder contractions recorded isometrically in the anesthetized rat. This 
      substance also antagonized the inhibition of spontaneous bladder contractions 
      produced by submaximal i.c.v. doses of the highly selective mu opioid agonist 
      [D-Ala2-MePhe4,Gly-(ol)5]enkephalin (DAGO) and the delta opioid agonist 
      [D-Pen2,D-Pen5]enkephalin (DPDPE). The antagonism of DAGO was reversible but that 
      of DPDPE lasted up to 30 h. These data suggest that endogenous opioids are 
      involved in the central control of bladder motility and that naloxonazine is a 
      long-lasting delta opioid receptor antagonist.
FAU - Dray, A
AU  - Dray A
FAU - Nunan, L
AU  - Nunan L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 36B82AMQ7N (Naloxone)
RN  - 82824-01-9 (naloxonazine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
SB  - IM
MH  - Animals
MH  - Central Nervous System/*drug effects/physiology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalins/antagonists & inhibitors
MH  - Female
MH  - Naloxone/*analogs & derivatives/pharmacology
MH  - Neural Inhibition
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Opioid/*drug effects/physiology
MH  - Receptors, Opioid, delta
MH  - Urinary Bladder/*innervation/physiology
EDAT- 1984/12/03 00:00
MHDA- 1984/12/03 00:01
CRDT- 1984/12/03 00:00
PHST- 1984/12/03 00:00 [pubmed]
PHST- 1984/12/03 00:01 [medline]
PHST- 1984/12/03 00:00 [entrez]
AID - 0006-8993(84)90273-7 [pii]
AID - 10.1016/0006-8993(84)90273-7 [doi]
PST - ppublish
SO  - Brain Res. 1984 Dec 3;323(1):123-7. doi: 10.1016/0006-8993(84)90273-7.