PMID- 6099272
OWN - NLM
STAT- MEDLINE
DCOM- 19850426
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 106
IP  - 1
DP  - 1984 Oct 30
TI  - Adenosine mechanisms in the regulation of breathing in the rat.
PG  - 59-67
AB  - The central respiratory effects of various adenosine (A) analogues were studied 
      in halothane-anesthetized rats. Intracerebroventricular (i.c.v.) and 
      intraperitoneal (i.p.) injections of the A analogues (2-Cla, L-PIA, CHA and NECA) 
      reduced minute ventilation (VE) due to decreases in respiratory frequency (f) as 
      well as tidal volume (VT). Dose-dependent effects were seen after i.c.v. L-PIA in 
      both normal and vagotomized rats. Analysis of the A-induced changes using the 
      occluded breath technique revealed an increase in expiratory time (TE) as well as 
      a decrease in inspiratory drive. NECA, a relatively specific A2 agonist seemed to 
      be somewhat more potent in eliciting respiratory depression than a relatively 
      specific A1 agonist like L-PIA. Pretreatment with the methylxanthine theophylline 
      completely antagonized the respiratory depression induced by L-PIA. It is 
      concluded that central A receptors are involved in the central regulation of 
      breathing and that A interacts with the respiratory control system mainly by 
      decreasing inspiratory neural drive and prolonging expiratory time.
FAU - Wessberg, P
AU  - Wessberg P
FAU - Hedner, J
AU  - Hedner J
FAU - Hedner, T
AU  - Hedner T
FAU - Persson, B
AU  - Persson B
FAU - Jonason, J
AU  - Jonason J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Purinergic)
RN  - 0 (Xanthines)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 29193-86-0 (Phenylisopropyladenosine)
RN  - C137DTR5RG (Theophylline)
RN  - DT7DT5E518 (enprofylline)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/analogs & derivatives/*pharmacology
MH  - Animals
MH  - Blood Gas Analysis
MH  - Blood Pressure/drug effects
MH  - Carbon Dioxide/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Male
MH  - Phenylisopropyladenosine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Cell Surface/drug effects
MH  - Receptors, Purinergic
MH  - Respiration/*drug effects
MH  - Respiratory Function Tests
MH  - Stereoisomerism
MH  - Theophylline/pharmacology
MH  - Xanthines/pharmacology
EDAT- 1984/10/30 00:00
MHDA- 1984/10/30 00:01
CRDT- 1984/10/30 00:00
PHST- 1984/10/30 00:00 [pubmed]
PHST- 1984/10/30 00:01 [medline]
PHST- 1984/10/30 00:00 [entrez]
AID - 0014-2999(84)90678-2 [pii]
AID - 10.1016/0014-2999(84)90678-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1984 Oct 30;106(1):59-67. doi: 10.1016/0014-2999(84)90678-2.