PMID- 6099500
OWN - NLM
STAT- MEDLINE
DCOM- 19850426
LR  - 20190913
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 5
IP  - 1-3
DP  - 1984 Dec
TI  - Electroencephalographic assessment of the role of delta receptors in opioid 
      peptide - induced seizures.
PG  - 213-6
AB  - DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are 
      conformationally-constrained cyclic analogs of enkephalin with high selectivity 
      for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of 
      each analog acutely produces a complex EEG response in rats characterized by a 
      dose-related increase in spectral power and HVSA (peak frequency of 5.0 Hz) 
      during behavioral stupor, and a theta driving (5.25-8.0 Hz) associated with 
      intense behavioral arousal. These effects were antagonized by high (10 mg/kg), 
      but not low (1.0 mg/kg), doses of naloxone. Both analogs failed to cause EEG or 
      convulsive seizures. In contrast, i.c.v. administration of DADLE ([D-Ala2, 
      D-Leu5]-Enkephalin), an enkephalin analog with activity at both mu and delta 
      binding sites, caused initial nonconvulsive EEG seizures followed by HVSA (3.0 
      Hz); theta driving was not evident. The incidence of the seizures was 
      dose-related and antagonized by very low doses of naloxone (0.01-1.0 mg/kg). 
      Collectively, the inability of DPDPE and DPLPE to cause seizure activity, and the 
      marked sensitivity of DADLE-induced EEG seizures to naloxone, suggest that delta 
      receptors are not directly responsible for DADLE-induced EEG seizure activity. 
      Furthermore, these data implicate mu opioid receptors as the primary sites 
      responsible for enkephalin-induced seizures.
FAU - Tortella, F C
AU  - Tortella FC
FAU - Robles, L
AU  - Robles L
FAU - Mosberg, H I
AU  - Mosberg HI
FAU - Holaday, J W
AU  - Holaday JW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 63631-40-3 (Enkephalin, Leucine-2-Alanine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
SB  - IM
MH  - Animals
MH  - Electroencephalography
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalin, Leucine/analogs & derivatives/pharmacology
MH  - Enkephalin, Leucine-2-Alanine
MH  - Enkephalins/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Opioid/drug effects/*physiology
MH  - Receptors, Opioid, delta
MH  - Seizures/*chemically induced/physiopathology
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 0143-4179(84)90065-9 [pii]
AID - 10.1016/0143-4179(84)90065-9 [doi]
PST - ppublish
SO  - Neuropeptides. 1984 Dec;5(1-3):213-6. doi: 10.1016/0143-4179(84)90065-9.