PMID- 6100738
OWN - NLM
STAT- MEDLINE
DCOM- 19860625
LR  - 20061115
IS  - 0952-1178 (Print)
IS  - 0952-1178 (Linking)
VI  - 2
IP  - 3
DP  - 1984 Dec
TI  - Sympathetic activation following central vasopressin receptor stimulation in 
      conscious rats.
PG  - S25-7
AB  - Vasopressin (AVP)-containing pathways from hypothalamic neurons have been shown 
      to project to blood pressure controlling brain centres. This suggests that AVP 
      neurons may be involved in central blood pressure regulation. The effects of 
      central AVP receptor stimulation on blood pressure, heart rate and directly 
      recorded efferent sympathetic nerve activity in the splanchnic nerve (SNA) were 
      investigated in conscious chronically instrumented rats. Intracerebroventricular 
      (i.c.v.) injections of AVP (1-100 ng) caused dose-dependent blood pressure 
      increases (maximum 26.9 +/- 3.5 mmHg) together with marked rises in heart rate 
      and SNA. More pre-treatment with the AVP receptor antagonist d(CH2)5AVP 
      (3/micrograms i.c.v.) completely prevented the central responses to AVP. 
      Intracarotid injection of the same AVP doses produced rises in blood pressure 
      accompanied by drastic falls in heart rate and SNA, similar to those seen after 
      i.v. AVP injection. Thus, stimulation of specific neuronal AVP receptors produces 
      a characteristic haemodynamic and sympathetic response pattern with marked 
      sympathetic nerve activation, which is clearly distinct from the responses to 
      vascular AVP receptor stimulation. It is concluded that AVP pathways in the brain 
      can contribute to central blood pressure control via regulation of sympathetic 
      outflow to the periphery.
FAU - Unger, T
AU  - Unger T
FAU - Rohmeiss, P
AU  - Rohmeiss P
FAU - Becker, H
AU  - Becker H
FAU - Ganten, D
AU  - Ganten D
FAU - Lang, R E
AU  - Lang RE
FAU - Petty, M
AU  - Petty M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hypertens Suppl
JT  - Journal of hypertension. Supplement : official journal of the International 
      Society of Hypertension
JID - 8501422
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Vasopressin)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Brain/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/*drug effects
MH  - Receptors, Cell Surface/*drug effects
MH  - Receptors, Vasopressin
MH  - Stimulation, Chemical
MH  - Sympathetic Nervous System/*drug effects
MH  - Wakefulness/*drug effects
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
PST - ppublish
SO  - J Hypertens Suppl. 1984 Dec;2(3):S25-7.