PMID- 6106427
OWN - NLM
STAT- MEDLINE
DCOM- 19801125
LR  - 20131121
IS  - 0300-5704 (Print)
IS  - 0300-5704 (Linking)
VI  - 10
IP  - 5
DP  - 1980 May
TI  - [The influence of aging, post-mortem delay until isolation of the tissue and 
      duration of agony on some glycolytic enzymes in human autoptic brain tissue 
      (author's transl)].
PG  - 203
AB  - The influence of aging and pre- and post-mortem conditions on the activities of 
      glycolytic enzymes and of the ATPases was determined in samples of autoptic human 
      cerebral cortex and putamen. These results were compared with results obtained 
      from an aging collective of rats (four groups ranging from 20 to 120 weeks of 
      age). The results revealed an interlinked significant age-related increase in 
      soluble hexokinase (HK) and a significant decrease in phosphofructokinase (PFK) 
      activity in human autoptic tissue, whereas no significant age-dependent 
      differences could be observed in rat brain. Subdivision of the cases according to 
      duration of agony and other pre-mortem conditions revealed reduced variance and 
      therefore statistically more significant PFK age-dependence in cases with a short 
      agony. All other cases are not dependent on age. In addition to the pre- and 
      post-mortem effects, the age-dependence of PFK and soluble HK can be clearly 
      demonstrated in human autoptic brain tissue.
FAU - Iwangoff, P
AU  - Iwangoff P
FAU - Enz, A
AU  - Enz A
FAU - Armbruster, R
AU  - Armbruster R
FAU - Emmenegger, H
AU  - Emmenegger H
FAU - Pataki, A
AU  - Pataki A
FAU - Sandoz, P
AU  - Sandoz P
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Der Einfluss von Alter, Zeitspanne bis zur postmortalen Isolierung des Gewebes 
      sowie der Agonie auf einige glycolytische Enzyme in autoptischen Gehirnproben des 
      Menschen.
PL  - Germany
TA  - Aktuelle Gerontol
JT  - Aktuelle Gerontologie
JID - 0421403
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
SB  - IM
MH  - Adenosine Triphosphatases/metabolism
MH  - Adenosine Triphosphate/metabolism
MH  - Adult
MH  - Aged
MH  - *Aging
MH  - Animals
MH  - Brain/*enzymology
MH  - Cerebral Cortex/enzymology
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - Pain/*enzymology
MH  - Phosphofructokinase-1/*metabolism
MH  - *Postmortem Changes
MH  - Putamen/enzymology
MH  - Rats
EDAT- 1980/05/01 00:00
MHDA- 1980/05/01 00:01
CRDT- 1980/05/01 00:00
PHST- 1980/05/01 00:00 [pubmed]
PHST- 1980/05/01 00:01 [medline]
PHST- 1980/05/01 00:00 [entrez]
PST - ppublish
SO  - Aktuelle Gerontol. 1980 May;10(5):203.