PMID- 6106541
OWN - NLM
STAT- MEDLINE
DCOM- 19801218
LR  - 20191031
IS  - 0148-3927 (Print)
IS  - 0148-3927 (Linking)
VI  - 2
IP  - 2
DP  - 1980 Feb
TI  - Pre- and postsynaptic alpha-adrenoceptor antagonists: differentiated 
      cardiovascular effects in the rat.
PG  - 273-96
AB  - Intravenous (i.v.) injections of yohimbine, phentolamine, prazosine and 
      phenoxybenzamine lowered blood pressure and increased heart rate in conscious 
      rats. Intracerebroventricular (i.c.v.) injections of yohimbine and phentolamine 
      increased blood pressure and heart rate; this was antogonized by pretreatment 
      with clonidine. Phenoxybenzamine and prozosine had no effect or gave hypotension 
      and tachycardia on i.c.v. injection. Pentobarbitone anaesthesia partly 
      antagonized the cardiovascular effects of all alpha-adrenoceptor antagonist. 
      Synthesis and utilization of central noradrenaline was increased by i.v. or 
      i.c.v. yohimbine; anaesthesia partly antagonized this effect. In peripheral 
      tissues others have found that yohimbine, tolazoline, piperoxan and phentolamine 
      are potent blockers of the presynaptic alpha-adrenoceptors while phenoxybenzamine 
      and prazosine act preferentially on postsynaptic alpha-adrenoceptors. The 
      differentiated cardiovascular response to i.c.v. injection of these blockers may 
      reflect their different affinity to central pre- and postsynaptic 
      alpha-adrenoceptors.
FAU - Gomes, C
AU  - Gomes C
FAU - Trolin, G
AU  - Trolin G
FAU - Henning, M
AU  - Henning M
FAU - Persson, B
AU  - Persson B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Exp Hypertens (1978)
JT  - Clinical and experimental hypertension
JID - 7803060
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0TTZ664R7Z (Phenoxybenzamine)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - I4744080IR (Pentobarbital)
RN  - MN3L5RMN02 (Clonidine)
RN  - XM03YJ541D (Prazosin)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/administration & dosage/*pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Clonidine/pharmacology
MH  - Heart Rate/*drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Pentobarbital/pharmacology
MH  - Phenoxybenzamine/pharmacology
MH  - Phentolamine/antagonists & inhibitors/pharmacology
MH  - Prazosin/pharmacology
MH  - Premedication
MH  - Rats
MH  - Receptors, Adrenergic/*drug effects
MH  - Receptors, Adrenergic, alpha/*drug effects
MH  - Yohimbine/antagonists & inhibitors/pharmacology
EDAT- 1980/02/01 00:00
MHDA- 1980/02/01 00:01
CRDT- 1980/02/01 00:00
PHST- 1980/02/01 00:00 [pubmed]
PHST- 1980/02/01 00:01 [medline]
PHST- 1980/02/01 00:00 [entrez]
AID - 10.3109/10641968009046424 [doi]
PST - ppublish
SO  - Clin Exp Hypertens (1978). 1980 Feb;2(2):273-96. doi: 10.3109/10641968009046424.