PMID- 6107454
OWN - NLM
STAT- MEDLINE
DCOM- 19810116
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 2
IP  - 8198
DP  - 1980 Oct 11
TI  - Search for canine-distemper-virus antibodies in multiple sclerosis. A detailed 
      virological evaluation.
PG  - 772-5
AB  - Sera and cerebrospinal fluid samples from multiple-sclerosis (MS) patients, 
      matched controls, and subacute sclerosing panencephalitis (SSPE) patients were 
      analysed for the presence of antibodies specific for measles and canine distemper 
      virus (CDV). Virus-specific antibodies were identified by haemagglutination 
      inhibition, neutralisation, and immune precipitation in combination with 
      polyacrylamide-gel electrophoresis. SSPE and MS patients had a higher antibody 
      activity towards measles virus than controls. Moreover, human sera partly 
      neutralised CDV; this was attributed to antibody activity against CDV proteins, 
      antigenically related to those of measles virus. However, CDV-specific antibodies 
      were not found in the samples tested. These findings indicate that MS can develop 
      without a preceding CDV infection.
FAU - Stephenson, J R
AU  - Stephenson JR
FAU - ter Meulen, V
AU  - ter Meulen V
FAU - Kiessling, W
AU  - Kiessling W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Antibodies, Viral/*analysis/cerebrospinal fluid
MH  - Antibody Specificity
MH  - Distemper Virus, Canine/*immunology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Female
MH  - Humans
MH  - Male
MH  - Measles virus/immunology
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*immunology
MH  - Subacute Sclerosing Panencephalitis/immunology
EDAT- 1980/10/11 00:00
MHDA- 1980/10/11 00:01
CRDT- 1980/10/11 00:00
PHST- 1980/10/11 00:00 [pubmed]
PHST- 1980/10/11 00:01 [medline]
PHST- 1980/10/11 00:00 [entrez]
AID - 10.1016/s0140-6736(80)90387-6 [doi]
PST - ppublish
SO  - Lancet. 1980 Oct 11;2(8198):772-5. doi: 10.1016/s0140-6736(80)90387-6.