PMID- 6108363
OWN - NLM
STAT- MEDLINE
DCOM- 19810219
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 215
IP  - 3
DP  - 1980 Dec
TI  - Histaminergic mechanisms involved in the centrally mediated effects of ouabain.
PG  - 552-6
AB  - The role of central histaminergic mechanisms in cardiac glycoside toxicity was 
      evaluated in chloralose-urethane anesthetized cats. Cardiac rhythm, blood 
      pressure and sympathetic nerve activity were monitored during continuous i.v. 
      infusion of ouabain (1 microgram/kg/min). Histamine administered into the fourth 
      cerebral ventricle decreased significantly the dose of ouabain necessary to 
      produce ventricular arrhythmias and fibrillation. Toxicity potentiation was 
      associated with enhancement of sympathetic efferent activity. Dimaprit, a 
      specific H2 receptor agonist, produced a similar, but slightly greater, 
      potentiation of ouabain activity than histamine when similarly administered. 
      Intracerebroventricular (i.c.v.) pretreatment of cats with cimetidine, an H2 
      receptor antagonist, provided a dose-dependent protective effect against 
      ouabain-induced toxicity. Central administration of diphenhydramine, an H1 
      receptor antagonist, had no effect on cardiotoxic actions. These results suggest 
      a role for central histaminergic mechanisms in cardiac glycoside toxicity which 
      is mediated through an H2 receptor process. Furthermore, it is suggested that 
      ouabain stimulates central histaminergic neurons which impinge on hypothalamic 
      areas and such excitement results in a centrogenic activation of sympathetic 
      centers which is responsible for cardiac glycoside cardiotoxicity.
FAU - Tackett, R L
AU  - Tackett RL
FAU - Holl, J E
AU  - Holl JE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Receptors, Histamine)
RN  - 0 (Receptors, Histamine H2)
RN  - 5ACL011P69 (Ouabain)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/chemically induced
MH  - Cats
MH  - Female
MH  - Histamine/administration & dosage/*physiology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Hypothalamus/*drug effects
MH  - Male
MH  - Ouabain/*toxicity
MH  - Receptors, Histamine/*drug effects
MH  - Receptors, Histamine H2/*drug effects
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1980 Dec;215(3):552-6.