PMID- 6113267
OWN - NLM
STAT- MEDLINE
DCOM- 19810820
LR  - 20191101
VI  - 50
IP  - 2-4
DP  - 1981
TI  - The functional role of the noradrenergic neurons in the thermoregulatory circuits 
      in mice.
PG  - 113-37
AB  - Intracerebroventricular (i.c.v.) treatment of mice with 6-hydroxydopamine 
      (6-OHDA; 20--50 micrograms per mouse), which depletes brain noradrenaline (NA) 
      and DA, completely prevents or significantly diminishes the hypothermic effect of 
      various classes of drugs: dopaminomimetics--apomorphine (0.5--10 mg/kg), 
      piribedil (40--100 mg/kg), bromocriptine (3 to 10 mg/kg), CM 29-712 (2--10 
      mg/kg), d, l-amphetamine (1--2 mg/kg), and L-DOPA (10--100 mg/kg) in combination 
      with Ro 4-4602 (5--40 mg/kg); cholinomimetics--oxotremorine (0.04--0.05 mg/kg), 
      arecoline (5--10 mg/kg) and pilocarpine (2--3 mg/kg); 
      neuroleptics--chlorpromazine, promazine, perphenazine, chlorprothixene, 
      haloperidol, fluanisone (5--10 mg/kg); central alpha-adrenoblocker aceperone 
      (20--40 mg/kg); inhibitor of tyrosine-hydroxylase alpha-methyltyrosine (200--300 
      mg/kg); inhibitor of dopamine-beta-hydroxylase--disulfiram (150--250 mg/kg) and 
      FLA-63 (15--25 mg/kg). This antihypothermic effect was demonstrated up to 3 
      months after administration of 6-OHDA for DA-mimetics and neuroleptics and up to 
      3 weeks for cholinomimetics. The hypothermic effect of presumable GABA-mimetics 
      Phenybut (100--150 mg/kg) and Lioresal (10--25 mg/kg) was enhanced by a prior 
      6-OHDA treatment. Pretreatment of mice with desipramine (25 to 30 mg/kg i.p.), 
      protriptyline (20 mg/kg) or AW 15(1)1129 (15--20 mg/kg) 20--45 min before 6-OHDA 
      administration protects the central NA-ergic neurons from a destructive effect of 
      6-OHDA and partially or completely counteracts the antihypothermic as well as 
      prohypothermic (in the case of GABA-mimetics) effect of 6-OHDA. In rats 
      desipramine counteracted antihypothermic effect of 6-OHDA in the case of 
      piribedil, but not of apomorphine. Intracerebroventricular treatment of mice with 
      a low (15 microgram) dose of 5, 6-dihydroxytryptamine (5, 6-DHT) enhanced the 
      hypothermic effects of DA-mimetics; higher doses of 5, 6-DHT (26 and 30 
      micrograms) and 5, 7-DHT (40 and 46 micrograms) diminished the hypothermic 
      effects; the antihypothermic effect of 6-OHDA was stronger than that of equimolar 
      doses of 5, 6- or 5,7-DHT; desipramine pretreatment counteracted antihypothermic 
      effects of 5, 6-DHT and 5, 7-DHT as well as depletion of brain NA they produce. 
      The data presented reveal the key position for NA-ergic neurons in a temperature 
      regulation and, particularly, in effects of various drugs on body temperature in 
      mice. The tentative fragment of the neuronal thermoregulatory circuit is proposed 
      in attempt to account for the presented an other known data concerning drug 
      action (and interactions) on core temperature in mice.
FAU - Schelkunov, E L
AU  - Schelkunov EL
FAU - Andreeva, O G
AU  - Andreeva OG
FAU - Korovin, K F
AU  - Korovin KF
FAU - Ostroumova, M N
AU  - Ostroumova MN
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - J Neural Transm
JT  - Journal of neural transmission
JID - 0337042
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Biogenic Amines)
RN  - 0 (Hydroxydopamines)
RN  - 3A64E3G5ZO (Bromocriptine)
RN  - 46627O600J (Levodopa)
RN  - DO22K1PRDJ (Piribedil)
RN  - N21FAR7B4S (Apomorphine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/pharmacology
MH  - Apomorphine/pharmacology
MH  - Biogenic Amines/metabolism
MH  - *Body Temperature Regulation/drug effects
MH  - Brain/*physiology
MH  - Bromocriptine/pharmacology
MH  - Female
MH  - Hydroxydopamines/metabolism
MH  - Kinetics
MH  - Levodopa/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neurons/drug effects/*physiology
MH  - Norepinephrine/*metabolism
MH  - Piribedil/pharmacology
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.1007/BF01249134 [doi]
PST - ppublish
SO  - J Neural Transm. 1981;50(2-4):113-37. doi: 10.1007/BF01249134.