PMID- 6113765
OWN - NLM
STAT- MEDLINE
DCOM- 19810827
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 240
IP  - 6
DP  - 1981 Jun
TI  - Myoelectric properties of the cat ileocecal sphincter.
PG  - G450-8
AB  - Myoelectric activity and intraluminal pressures were recorded simultaneously from 
      the ileum, ileocecal sphincter (ICS), and proximal colon in 
      chloralose-anesthetized cats. Slow-wave activity, seen at all areas, showed 
      coupling of frequency in the distal ileum and ICS. ICS spike activity was both 
      isolated and associated with ileal or colonic spike activity and correlated with 
      phasic contractions (r = 0.86; P less than 0.01). Ileal distensions caused ICS 
      relaxation and decreased spike activity 33.8% of the time. Colonic distensions 
      caused contraction and increased spike activity 46.9% of the time. Migrating 
      action-potential complexes (MAPC) induced by castor oil, ricinoleic acid, or 
      cholecystokinin propagated to the ICS and through to the colon significantly more 
      frequently than ileal non-MAPC (P less than 0.05). Both spike potential-dependent 
      and spike potential-independent mechanisms were involved in ICS contraction. 
      Bethanechol increased spike activity and phasic and tonic contractions. 
      Phenylephrine, despite loss of spike activity in all leads, caused tonic 
      contraction of the ICS. Isoproterenol caused loss of spike activity and decreased 
      ICS pressure. Thus, ICS myoelectric activity appears to be important in 
      determining sphincter function during neurohumoral and mechanical stimulation, 
      with ICS contractions occurring through both a phasic spike-related mechanism and 
      a tonic mechanism without spike activity.
FAU - Ouyang, A
AU  - Ouyang A
FAU - Snape, W J Jr
AU  - Snape WJ Jr
FAU - Cohen, S
AU  - Cohen S
LA  - eng
GR  - R01-AM-19379/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Bethanechol Compounds)
RN  - 004F72P8F4 (Bethanechol)
RN  - 1WS297W6MV (Phenylephrine)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Bethanechol
MH  - Bethanechol Compounds/pharmacology
MH  - Cats
MH  - Cecum/drug effects/*physiology
MH  - Colon/*physiology
MH  - Electric Conductivity
MH  - Female
MH  - Gastrointestinal Motility
MH  - Ileum/drug effects/*physiology
MH  - Isoproterenol/pharmacology
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Phenylephrine/pharmacology
MH  - Pressure
EDAT- 1981/06/11 19:15
MHDA- 1981/06/11 19:16
CRDT- 1981/06/11 19:15
PHST- 1981/06/11 19:15 [pubmed]
PHST- 1981/06/11 19:16 [medline]
PHST- 1981/06/11 19:15 [entrez]
AID - 10.1152/ajpgi.1981.240.6.G450 [doi]
PST - ppublish
SO  - Am J Physiol. 1981 Jun;240(6):G450-8. doi: 10.1152/ajpgi.1981.240.6.G450.