PMID- 6113790
OWN - NLM
STAT- MEDLINE
DCOM- 19810810
LR  - 20190913
IS  - 0303-4569 (Print)
IS  - 0303-4569 (Linking)
VI  - 13
IP  - 2
DP  - 1981 Mar-Apr
TI  - The effect of alpha-difluromethylornithine and tartaric acid on sperm count, 
      seminal gamma GT, FSH, LH, testosterone and steroid excretion in patients with 
      chronic prostatitis.
PG  - 100-7
AB  - The inactivation of ornithine decarboxylase, a polyamine biosynthetic enzyme, by 
      alpha-difluoromethylornithine (alpha-DFMO) was studied in patients with chronic 
      non-suppurative prostatitis. Partial clinical response and remission of gross 
      hematospermia were observed after 18 g/day alpha-DFMO, when administered orally 
      for 1 month. The determination of gamma-glutamyltransferase, LH, Testosterone in 
      semen and also of sperm motility and vitality appeared distinctly changed in 
      alpha-DFMO treated patients, indicating a significant effect on the activity of 
      the prostate. -- A 16% decrease of hematocrit and hemoglobin in 2 out of 10 
      patients was reversible 2 months after stopping the therapy. The placebo, which 
      was identified mainly as tartaric acid after termination of the study showed 
      similar clinical response and change of seminal parameters. The modulation of 
      sperm count, seminal gamma GT, LH and testosterone was correlated to the known 
      inhibition of prostatic acid phosphatase by tartaric acid in vitro.
FAU - Dunzendorfer, U
AU  - Dunzendorfer U
FAU - Feller, H
AU  - Feller H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Ornithine Decarboxylase Inhibitors)
RN  - 0 (Steroids)
RN  - 0 (Tartrates)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - E524N2IXA3 (Ornithine)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - ZQN1G5V6SR (Eflornithine)
SB  - IM
MH  - Adult
MH  - Eflornithine
MH  - Follicle Stimulating Hormone/*metabolism
MH  - Humans
MH  - Luteinizing Hormone/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Ornithine/*analogs & derivatives/therapeutic use
MH  - Ornithine Decarboxylase Inhibitors
MH  - Prostatitis/*drug therapy/metabolism
MH  - Sperm Count
MH  - Steroids/*metabolism
MH  - Tartrates/therapeutic use
MH  - Testosterone/*metabolism
MH  - gamma-Glutamyltransferase/*metabolism
EDAT- 1981/03/01 00:00
MHDA- 1981/03/01 00:01
CRDT- 1981/03/01 00:00
PHST- 1981/03/01 00:00 [pubmed]
PHST- 1981/03/01 00:01 [medline]
PHST- 1981/03/01 00:00 [entrez]
AID - 10.1111/j.1439-0272.1981.tb00014.x [doi]
PST - ppublish
SO  - Andrologia. 1981 Mar-Apr;13(2):100-7. doi: 10.1111/j.1439-0272.1981.tb00014.x.