PMID- 6117180
OWN - NLM
STAT- MEDLINE
DCOM- 19811222
LR  - 20041117
IS  - 0300-8967 (Print)
IS  - 0300-8967 (Linking)
VI  - 81
IP  - 2
DP  - 1981 Mar-Apr
TI  - Some aspects of the French contribution during the past ten years to the study 
      and use of injectable long-acting neuroleptics.
PG  - 103-14
AB  - Out of five injectable long-acting neuroleptics (LANs) in general use in France, 
      two are french derivatives. LANs in France have been introduced at high dosages, 
      because of the administration of high doses of oral activating neuroleptics at 
      that time. Despite the apparent lack of relationship between dosage and adverse 
      effects, the clinical use of LANs has nowadays moved to lower doses, probably 
      because of the treatment of a greater proportion of less severely-ill outpatients 
      and of patients at an early stage. The "sectorial" organization of community 
      psychiatry in France has contributed to the low-dose LAN strategy. French authors 
      pointed to an original indication of LANs, namely very low dosages in chronic 
      alcoholism characterized by a high frequency of early personality disorders, such 
      as paranoid or psychopathic traits. Adverse reactions are more pronounced in such 
      patients at high dosages, esp. depression and sedation. The authors have been the 
      first ones to report the incidence of depressive reactions in prolonged 
      treatments with LANs (1967). Malignant hyperthermia, though rare, has been 
      related to a direct onset of treatment with a LAN and not to its dosage.
FAU - Lambert, P A
AU  - Lambert PA
FAU - Guinot, G
AU  - Guinot G
FAU - Chabannes, J P
AU  - Chabannes JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Belgium
TA  - Acta Psychiatr Belg
JT  - Acta psychiatrica Belgica
JID - 0247037
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Phenothiazines)
SB  - IM
MH  - Alcoholism/drug therapy
MH  - Animals
MH  - Antipsychotic Agents/*administration & dosage/adverse effects/therapeutic use
MH  - Delayed-Action Preparations
MH  - Depression/chemically induced
MH  - Dose-Response Relationship, Drug
MH  - France
MH  - Humans
MH  - Injections
MH  - Malignant Hyperthermia/*chemically induced
MH  - Mental Disorders/drug therapy
MH  - Phenothiazines
MH  - Rats
MH  - Time Factors
RF  - 23
EDAT- 1981/03/01 00:00
MHDA- 1981/03/01 00:01
CRDT- 1981/03/01 00:00
PHST- 1981/03/01 00:00 [pubmed]
PHST- 1981/03/01 00:01 [medline]
PHST- 1981/03/01 00:00 [entrez]
PST - ppublish
SO  - Acta Psychiatr Belg. 1981 Mar-Apr;81(2):103-14.