PMID- 6117183
OWN - NLM
STAT- MEDLINE
DCOM- 19811222
LR  - 20041117
IS  - 0300-8967 (Print)
IS  - 0300-8967 (Linking)
VI  - 81
IP  - 2
DP  - 1981 Mar-Apr
TI  - Eleven years of experience with depot neuroleptics.
PG  - 128-32
AB  - The authors prescribe depot neuroleptics almost exclusively to chronic 
      schizophrenics; the minimum duration of treatment is 6 months; 63% of long-acting 
      neuroleptics are fluphenazine decanoate or flupentixol decanoate (main 
      indication: inactive schizophrenics), 37% are clopentixol decanoate (main 
      indication: productive and agitated schizophrenics). Safety, compliance and 
      pharmacokinetics are much better with long-acting neuroleptics (LANs) than with 
      oral medications, but the authors question the reality of a dose reduction as 
      compared to oral neuroleptics since the latter are taken irregularly. The lowest 
      possible dose and an increase of intervals between injections are advocated, 
      because of less cumulative effects and less tardive dyskinesias. LANs bring about 
      a quantitative reduction of symptomatology, but not a cure of the schizophrenic 
      process: most patients relapse upon discontinuation.
FAU - Gross, H
AU  - Gross H
FAU - Kaltenback, E
AU  - Kaltenback E
FAU - Pfolz, H
AU  - Pfolz H
LA  - eng
PT  - Journal Article
PL  - Belgium
TA  - Acta Psychiatr Belg
JT  - Acta psychiatrica Belgica
JID - 0247037
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Delayed-Action Preparations)
SB  - IM
MH  - Antipsychotic Agents/*administration & dosage/therapeutic use
MH  - Delayed-Action Preparations
MH  - Humans
MH  - Schizophrenia/*drug therapy
EDAT- 1981/03/01 00:00
MHDA- 1981/03/01 00:01
CRDT- 1981/03/01 00:00
PHST- 1981/03/01 00:00 [pubmed]
PHST- 1981/03/01 00:01 [medline]
PHST- 1981/03/01 00:00 [entrez]
PST - ppublish
SO  - Acta Psychiatr Belg. 1981 Mar-Apr;81(2):128-32.