PMID- 6120087
OWN - NLM
STAT- MEDLINE
DCOM- 19820412
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 45
IP  - 1-2
DP  - 1982
TI  - The action of six antagonists of the excitatory amino acids on neurones of the 
      rat spinal cord.
PG  - 151-6
AB  - The differential susceptibility to blockade by six antagonists of the excitatory 
      actions produced by a number of acidic amino acids has been determined. Four of 
      these, DL-alpha-aminoadipate, 2-amino-5-phosphonovalerate, 
      2-amino-6-phosphonocaproate and gamma-D-glutamylglycine block the action of 
      N-methyl-D-aspartate (NMDA) most effectively and those of L-glutamate, 
      trans-1-amino-1,3-dicarboxycyclopentane (trans-ADCP) and kainate the least. 
      Cis-2,3-piperidine dicarboxylate resembles the other four, save in that kainate 
      excitations are also powerfully blocked. L-glutamate diethylester was most 
      effective against L-glutamate and least against NMDA: kainate and trans-ADCP 
      excitations were also relatively unaffected. The data support the hypothesis of 
      the existence of at least three classes of amino acid receptor (NMDA-, 
      L-glutamate- and kainate-excited), and the possibility of a fourth category 
      activated by trans-ADCP must be considered.
FAU - McLennan, H
AU  - McLennan H
FAU - Liu, J
AU  - Liu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Amino Acids)
RN  - 0 (Glutamates)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Kainic Acid/pharmacology
MH  - N-Methylaspartate
MH  - Neurons/drug effects/*physiology
MH  - Rats
MH  - Spinal Cord/drug effects/*physiology
MH  - Structure-Activity Relationship
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00235774 [doi]
PST - ppublish
SO  - Exp Brain Res. 1982;45(1-2):151-6. doi: 10.1007/BF00235774.