PMID- 6121300
OWN - NLM
STAT- MEDLINE
DCOM- 19820527
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 21
IP  - 1
DP  - 1982 Jan
TI  - Histamine-induced rise in core temperature of chloral-anaesthetized rats: 
      mediation by H2-receptors located in the preopticus area of hypothalamus.
PG  - 45-50
AB  - Intracerebroventricular (i.c.v.) administration of histamine in chloral 
      anaesthetized rats exposed to an ambient temperature of 22 C elicited a rise in 
      their colonic temperature associated with a shivering. This effect was shared by 
      the H2 receptor agonists dimaprit and impromidine. Impromidine is, in this 
      respect, a partial agonist with an ED50 much lower than histamine. The 
      histamine-induced rise in core temperature was antagonized by cimetidine 
      administered either centrally (in doses of 25-40 micrograms, i.c.v.) or 
      peripherally (large doses greater than or equal to 50 mg/kg i.p.) This 
      constitutes an indication for the crossing of the blood-brain barrier by 
      cimetidine. The H2 histamine receptors involved in this effect seem to be located 
      mainly in the preopticus medialis nucleus (p.o.m.n.) of the hypothalamus since 
      bilateral microinjections of histamine (5 ng) into this nucleus induced the 
      effect, whereas cimetidine injected into the p.o.m.n., antagonised the relative 
      hyperthermia elicited by an intracerebroventricular administration of histamine.
FAU - Colboc, O
AU  - Colboc O
FAU - Protais, P
AU  - Protais P
FAU - Costentin, J
AU  - Costentin J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Guanidines)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Receptors, Histamine)
RN  - 0 (Receptors, Histamine H2)
RN  - 418M5916WG (Chloral Hydrate)
RN  - 820484N8I3 (Histamine)
RN  - 931L4X5WMM (Impromidine)
RN  - FLI06WS32H (trichloroacetaldehyde)
RN  - GYV9AM2QAG (Thiourea)
RN  - ZZQ699148P (Dimaprit)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Chloral Hydrate/analogs & derivatives/pharmacology
MH  - Dimaprit
MH  - Guanidines/pharmacology
MH  - Histamine/*pharmacology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Hypothalamus/*drug effects
MH  - Imidazoles/pharmacology
MH  - Impromidine
MH  - Male
MH  - Preoptic Area/*drug effects/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Histamine/*drug effects
MH  - Receptors, Histamine H2/*drug effects
MH  - Thiourea/pharmacology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1016/0028-3908(82)90209-x [doi]
PST - ppublish
SO  - Neuropharmacology. 1982 Jan;21(1):45-50. doi: 10.1016/0028-3908(82)90209-x.