PMID- 6121702
OWN - NLM
STAT- MEDLINE
DCOM- 19820614
LR  - 20190919
IS  - 0013-9432 (Print)
IS  - 0013-9432 (Linking)
VI  - 27
IP  - 2
DP  - 1982
TI  - Influence of age, sex and cancer on the activities of gamma-glutamyl 
      transpeptidase and of dipeptidyl aminopeptidase IV in rat tissues.
PG  - 114-8
AB  - gamma-Glutamyl transpeptidase (GTP; EC 2.3.2.2) is an enzyme known to show 
      activity changes during development and carcinogenesis. Its activity was measured 
      in the livers and lungs of female and male rats of different ages, in Morris 
      hepatomas and in experimentally induced pancreatic carcinomas. For comparison 
      purposes, the activity of another peptidase, dipeptidyl aminopeptidase IV (DPAP; 
      EC 3.4.14.1), was assayed in the same tissues. GTP activity was high in fetal 
      liver and hepatomas, but low in adult rat liver, with a marked sex difference, 3 
      times higher in the female than in the male. In the pancreas, however, the 
      activity of the enzyme was high in the adult but low in the fetus and in 
      pancreatic carcinoma. There were no marked developmental changes or sex 
      differences in pulmonary GTP activities. DPAP levels were low in fetal and 
      neonatal liver and lung, they increased rapidly after birth and showed no sex 
      differences in the adult. In Morris hepatomas and in pancreatic tumors the 
      activity of DPAP was significantly lower than in normal adult liver and pancreas. 
      These results suggest that measurements of GTP (and, to a lesser extent, DPAP) 
      are remarkably suitable for the study of neoplastic cells and tissues.
FAU - Fujiwara, K
AU  - Fujiwara K
FAU - Katyal, S L
AU  - Katyal SL
FAU - Lombardi, B
AU  - Lombardi B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Enzyme
JT  - Enzyme
JID - 1262265
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.14.- (Dipeptidyl-Peptidases and Tripeptidyl-Peptidases)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*metabolism
MH  - Endopeptidases/*metabolism
MH  - Female
MH  - Fetus/enzymology
MH  - Liver/enzymology
MH  - Liver Neoplasms, Experimental/enzymology
MH  - Lung/enzymology
MH  - Male
MH  - Neoplasms, Experimental/*enzymology
MH  - Pancreatic Neoplasms/enzymology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sex Factors
MH  - gamma-Glutamyltransferase/*metabolism
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1159/000459034 [doi]
PST - ppublish
SO  - Enzyme. 1982;27(2):114-8. doi: 10.1159/000459034.