PMID- 6121736
OWN - NLM
STAT- MEDLINE
DCOM- 19820621
LR  - 20201209
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 10
IP  - 2
DP  - 1982
TI  - Analgesia following adult tonsillectomy: a comparative study of solpadeine and a 
      soluble form of dextropropoxyphene napsylate and paracetamol.
PG  - 109-12
AB  - A single-centre, single blind, between-patient study was carried out to compare 
      the effectiveness and tolerability of Solpadeine and a soluble form of 
      dextropropoxyphene napsylate and paracetamol (DNP) in the alleviation of pain 
      following bilateral tonsillectomy in adult patients. Patients were randomly 
      allocated to receive either two Solpadeine or two DNP 6-hourly over a period of 3 
      days starting on the day after the operation. The clinician assessed the 
      patients' condition at the time of operation and again at the end of the 3-day 
      treatment period. The patients determined the onset of analgesic action using 
      visual analogue scales and also recorded the severity of their pain at various 
      times during the day. Seventy-four results were analyzed. Twenty per cent of 
      those receiving Solpadeine were considered by the clinician to have excellent 
      pain relief compared with only 8.8% on DNP. On Day 2, 51.3% of patients on 
      Solpadeine described the pain relief as good or excellent in comparison with 
      37.5% on DNP. However, these differences were not statistically significant. It 
      is concluded that Solpadeine and DNP are both effective analgesics in relieving 
      post-tonsillectomy pain, but that Solpadeine achieves a greater degree of good or 
      excellent pain relief and is, therefore, to be preferred.
FAU - MacKay, I S
AU  - MacKay IS
FAU - Ananian, V
AU  - Ananian V
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Analgesics)
RN  - 0 (Drug Combinations)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 3G6A5W338E (Caffeine)
RN  - 82400-20-2 (solpadeine)
RN  - S2F83W92TK (Dextropropoxyphene)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
MH  - Acetaminophen/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Analgesics
MH  - Caffeine/*therapeutic use
MH  - Codeine/*analogs & derivatives/therapeutic use
MH  - Dextropropoxyphene/*analogs & derivatives/*therapeutic use
MH  - Drug Combinations/therapeutic use
MH  - Drug Tolerance
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative/*drug therapy
MH  - Solubility
MH  - Tonsillectomy
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1177/030006058201000207 [doi]
PST - ppublish
SO  - J Int Med Res. 1982;10(2):109-12. doi: 10.1177/030006058201000207.