PMID- 6126228
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20061115
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 17
IP  - 7
DP  - 1982 Jul
TI  - Neuroleptic-induced lateral asymmetry of visual evoked potentials in 
      schizophrenia.
PG  - 815-28
AB  - Electrophysiological studies have shown asymmetric brain reactivity in 
      schizophrenia, supporting the hypothesis of left hemisphere hyperarousal in this 
      disease. It may be assumed, therefore, that neuroleptic treatment restores 
      hemispheric balance in schizophrenic patients by selectively suppressing the 
      hyperactive left hemisphere. This hypothesis was tested in the present study 
      which compared bilaterally recorded visual evoked potentials (VEP) in 9 
      non-medicated patients and 29 schizophrenics treated with various neuroleptic 
      drugs, as well as in 34 normal controls. In medicated patients later VEP 
      components showed enhancement over the right hemisphere as a function of the 
      overall dose (chlorpromazine equivalent) of neuroleptics. Reversed asymmetry was 
      seen in drug-free patients. In view of this result, some amendments of the 
      concept of left hemisphere hyperactivity in schizophrenia are proposed.
FAU - Mintz, M
AU  - Mintz M
FAU - Tomer, R
AU  - Tomer R
FAU - Myslobodsky, M S
AU  - Myslobodsky MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Piperazines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/*pharmacology
MH  - Brain/*drug effects/physiopathology
MH  - Evoked Potentials, Visual/*drug effects
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Piperazines/pharmacology
MH  - Schizophrenia/drug therapy/*physiopathology
EDAT- 1982/07/01 00:00
MHDA- 1982/07/01 00:01
CRDT- 1982/07/01 00:00
PHST- 1982/07/01 00:00 [pubmed]
PHST- 1982/07/01 00:01 [medline]
PHST- 1982/07/01 00:00 [entrez]
PST - ppublish
SO  - Biol Psychiatry. 1982 Jul;17(7):815-28.