PMID- 6131355
OWN - NLM
STAT- MEDLINE
DCOM- 19830421
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 31
IP  - 20-21
DP  - 1982 Nov 15-22
TI  - Differential cardiovascular effects of mu, delta and kappa opiate agonists at 
      discrete hypothalamic sites in the anesthetized rat.
PG  - 2197-200
AB  - Cardiovascular and respiratory activity of mu, delta and kappa opioid agonists 
      were investigated utilizing microinjections into the n. preopticus medialis (POM) 
      and periventricularis hypothalami (HPV) of anesthetized rats. Injections of the 
      relative mu agonists Morphine and Morphiceptin the delta agonist D-Ala2, 
      D-Leu5-Enkephalin (DADL) or the putative kappa agonist Dynorphin 1-13 into the 
      HPV caused hypotension and bradypnea; Morphine produced tachycardia while DADL 
      and Dynorphin bradycardia. In the POM, injections of Morphine or DADL increased 
      blood pressure and heart rate whereas Dynorphin caused hypotension and 
      bradycardia. At this site, the mu agonist D-Ala2-MePhe4-Gly5-ol-Enkephalin (DAGO) 
      produced hypotension, tachycardia and bradypnea, DAGO and DADL but not Morphine 
      or Dynorphin also caused bradypnea in this region. These data show that the 
      central cardiovascular and respiratory effects of opioids vary according to 
      injection site and opioid subtype and may differ from findings obtained using 
      cerebroventricular injections.
FAU - Feuerstein, G
AU  - Feuerstein G
FAU - Faden, A I
AU  - Faden AI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Endorphins)
RN  - 0 (Enkephalins)
RN  - 0 (Narcotics)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 63631-40-3 (Enkephalin, Leucine-2-Alanine)
RN  - 65189-64-2 (enkephalinamide-Leu, Ala(2)-)
RN  - 74913-18-1 (Dynorphins)
RN  - 76I7G6D29C (Morphine)
RN  - 97TZA8ANPC (morphiceptin)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Dynorphins
MH  - Endorphins/pharmacology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
MH  - Enkephalin, Leucine/analogs & derivatives/pharmacology
MH  - *Enkephalin, Leucine-2-Alanine/*analogs & derivatives
MH  - Enkephalins/pharmacology
MH  - Heart Rate/*drug effects
MH  - Hypothalamus/drug effects/*physiology
MH  - Male
MH  - Morphine/pharmacology
MH  - Narcotics/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Respiration/*drug effects
MH  - Structure-Activity Relationship
EDAT- 1982/11/15 00:00
MHDA- 1982/11/15 00:01
CRDT- 1982/11/15 00:00
PHST- 1982/11/15 00:00 [pubmed]
PHST- 1982/11/15 00:01 [medline]
PHST- 1982/11/15 00:00 [entrez]
AID - 0024-3205(82)90117-5 [pii]
AID - 10.1016/0024-3205(82)90117-5 [doi]
PST - ppublish
SO  - Life Sci. 1982 Nov 15-22;31(20-21):2197-200. doi: 10.1016/0024-3205(82)90117-5.