PMID- 6138730
OWN - NLM
STAT- MEDLINE
DCOM- 19831221
LR  - 20220523
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 22
IP  - 9
DP  - 1983 Sep
TI  - Studies on the mechanism of the cardiovascular action of central injections of 
      histamine.
PG  - 1109-15
AB  - The role of the sympathetic nervous system in the mediation of cardiovascular 
      function, following administration of histamine centrally was investigated. 
      Intracerebroventricular (i.c.v.) injections of histamine into the lateral 
      ventricle of conscious rats caused a dose-dependent increase in blood pressure as 
      well as a dose-dependent fall in heart rate. The pressure and heart rate 
      responses were both attenuated by pretreatment with chlorpheniramine. Peripheral 
      blockade of autonomic ganglia with hexamethonium failed to block the 
      centrally-mediated pressor response to histamine. Peripheral chemical 
      sympathectomy with 6-hydroxydopamine also did not inhibit the pressor response to 
      histamine. In this latter group of animals the pressor response to histamine was 
      potentiated. It is concluded that in the conscious rat, increased in blood 
      pressure resulting from central stimulation with histamine are not mediated 
      solely through the activation of the sympathetic nervous system and are, at least 
      in part, due to the release of a vasopressor substance.
FAU - Klein, M C
AU  - Klein MC
FAU - Gertner, S B
AU  - Gertner SB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Hexamethonium Compounds)
RN  - 0 (Histamine Antagonists)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 54-77-3 (Dimethylphenylpiperazinium Iodide)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Dimethylphenylpiperazinium Iodide/pharmacology
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Histamine/*pharmacology
MH  - Histamine Antagonists
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sympathectomy, Chemical
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - 10.1016/0028-3908(83)90032-1 [doi]
PST - ppublish
SO  - Neuropharmacology. 1983 Sep;22(9):1109-15. doi: 10.1016/0028-3908(83)90032-1.