PMID- 6140136
OWN - NLM
STAT- MEDLINE
DCOM- 19840224
LR  - 20031114
IS  - 0090-9556 (Print)
IS  - 0090-9556 (Linking)
VI  - 11
IP  - 6
DP  - 1983 Nov-Dec
TI  - Disposition of 4,4'-thiobis(6-t-butyl-m-cresol) in rats.
PG  - 537-43
AB  - The absorption, distribution, metabolism, and excretion of 14C-labeled 
      4,4'-thiobis(6-t-butyl-m-cresol) (TBBC) was studied in male rats. Oral treatment 
      showed a dose-related decrease in the rate of absorption due to a dose-related 
      increase in retention time in the stomach. TBBC was incompletely absorbed after 
      oral treatment, although the rate of absorption was proportional to the dose once 
      the compound reached the small intestine. TBBC was rapidly distributed throughout 
      the body with the liver being the major tissue depot. Significant amounts of the 
      compound were also present in blood, muscle, skin, and adipose tissue. TBBC was 
      initially rapidly cleared from all tissues except adipose, although a small 
      percentage of the total dose tended to persist in liver and skin. Over half of 
      the compound was excreted the first day, primarily via the bile into the feces. 
      Little TBBC-derived radioactivity appeared in the urine. Metabolites of TBBC were 
      present in the tissues at early times after administration, but were rapidly 
      excreted. The major metabolite(s) appeared to be glucuronide conjugates of the 
      parent compound. Thus, TBBC, an important antioxidant in the rubber and plastic 
      industries, would tend to accumulate in liver and lipid-rich tissues upon chronic 
      exposure, which if by the oral route, could also result in direct damage to the 
      gastrointestinal tract.
FAU - Birnbaum, L S
AU  - Birnbaum LS
FAU - Eastin, W C Jr
AU  - Eastin WC Jr
FAU - Johnson, L
AU  - Johnson L
FAU - Matthews, H B
AU  - Matthews HB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Drug Metab Dispos
JT  - Drug metabolism and disposition: the biological fate of chemicals
JID - 9421550
RN  - 0 (Cresols)
RN  - 96-69-5 (4,4'-thiobis(6-tert-butyl-3-cresol))
SB  - IM
MH  - Animals
MH  - Bile/metabolism
MH  - Biotransformation
MH  - Cresols/*metabolism
MH  - Feces/analysis
MH  - Intestinal Absorption
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1983/11/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
PST - ppublish
SO  - Drug Metab Dispos. 1983 Nov-Dec;11(6):537-43.