PMID- 6140178
OWN - NLM
STAT- MEDLINE
DCOM- 19840215
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 95
IP  - 3-4
DP  - 1983 Nov 25
TI  - Central alpha 1-adrenoceptors and cardiovascular control in normotensive and 
      spontaneously hypertensive rats.
PG  - 207-13
AB  - Intracerebroventricular (i.c.v.) injections of AR-C 239 (30 micrograms/kg), a 
      selective alpha 1-adrenoceptor blocking drug, did not modify the heart rate in 
      normotensive control (without pretreatment), bilaterally vagotomized and beta 
      blocked rats and in spontaneously hypertensive (SH) bilaterally vagotomized rats. 
      Intracisternal (i.c.) administrations of AR-C 239 (30 micrograms/kg) however 
      decreased the heart rate in normotensive beta blocked and in SH bilaterally 
      vagotomized rats. The differential effect on heart rate of i.c.v. versus i.c. 
      administration of AR-C 239 suggests a brainstem localization of the alpha 
      1-adrenoceptors involved. The binding of [3H]prazosin was significantly higher in 
      homogenates from whole brain and in membranes from the cerebral cortex and 
      hypothalamus of SH rats as compared to normotensive rats. In addition, the 
      binding of [125I]BE 2254, a new iodinated radioligand of high specific 
      radioactivity used to characterize alpha 1-adrenoceptors, was significantly 
      increased in membranes from the NTS of SH rats. These results suggest that 
      central alpha 1-adrenoceptors localized in the brainstem and in the hypothalamus 
      and the cortex play a role in the control of vagal tone in normotensive rats and 
      of sympathetic activity in SH animals. Thus, it is postulated that central alpha 
      1-adrenoceptors may participate in either the genesis or the maintenance of 
      genetic hypertension.
FAU - Huchet, A M
AU  - Huchet AM
FAU - Huguet, F
AU  - Huguet F
FAU - Ostermann, G
AU  - Ostermann G
FAU - Bakri-Logeais, F
AU  - Bakri-Logeais F
FAU - Schmitt, H
AU  - Schmitt H
FAU - Narcisse, G
AU  - Narcisse G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Isoquinolines)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - M7H349ZZ5T (AR-C239)
SB  - IM
MH  - Adrenergic alpha-Antagonists/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/*metabolism
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Hypertension/*physiopathology
MH  - In Vitro Techniques
MH  - Isoquinolines/*pharmacology
MH  - Male
MH  - *Piperazines
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, alpha/drug effects/*physiology
EDAT- 1983/11/25 00:00
MHDA- 1983/11/25 00:01
CRDT- 1983/11/25 00:00
PHST- 1983/11/25 00:00 [pubmed]
PHST- 1983/11/25 00:01 [medline]
PHST- 1983/11/25 00:00 [entrez]
AID - 0014-2999(83)90636-2 [pii]
AID - 10.1016/0014-2999(83)90636-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1983 Nov 25;95(3-4):207-13. doi: 10.1016/0014-2999(83)90636-2.