PMID- 6141117
OWN - NLM
STAT- MEDLINE
DCOM- 19840308
LR  - 20190721
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 101
IP  - 1
DP  - 1984 Jan
TI  - Transient expression of selected catecholaminergic traits in cranial sensory and 
      dorsal root ganglia of the embryonic rat.
PG  - 51-60
AB  - We describe the transient expression of catecholaminergic traits in cranial 
      sensory and dorsal root ganglia of the embryonic rat in vivo. Isolated cells 
      expressing tyrosine hydroxylase (T-OH) immunoreactivity were initially detected 
      in trigeminal (V) ganglion anlages as early as gestational Day 10.5 (E10.5; 18-22 
      somites). Neurofilament (NF) protein was also evident in V at these early stages. 
      By E11.5 (27-30 somites) clusters of T-OH-positive cells were visible in V. Many 
      of these cells were bipolar; others sent processes into the primitive brainstem. 
      In addition, cells expressing T-OH were apparent in primordia of sensory ganglia 
      serving the glossopharyngeal (IX) and vagal (X) cranial nerves. By this stage 
      (E11.5) all cranial sensory ganglia were rich in NF protein, but immunoreactivity 
      was confined to cellular processes rather than perikarya. By E12 (35-37 somites), 
      only a few, faintly positive T-OH-containing cells were evident in V. However, 
      DBH- and T-OH-positive cells were visible within the more caudal nodose and 
      petrosal ganglia. Furthermore, isolated bipolar cells expressing T-OH were 
      detected in rostral dorsal root ganglia at this stage. Catecholamine fluorescence 
      could not be detected in any sensory ganglia even after maternal treatment with 
      inhibitors of monoamine oxidase. Catecholaminergic cells were not seen at any 
      stage in anlages of the acousticovestibular nucleus. Immunoreactive T-OH was 
      undetectable in all ganglia by E13.5 (46-48 somites). These findings highlight 
      the fact that transient expression of the catecholamine phenotype during 
      development is a widespread phenomenon, evident in a variety of cell types of 
      diverse embryonic origin.
FAU - Jonakait, G M
AU  - Jonakait GM
FAU - Markey, K A
AU  - Markey KA
FAU - Goldstein, M
AU  - Goldstein M
FAU - Black, I B
AU  - Black IB
LA  - eng
GR  - HD12108/HD/NICHD NIH HHS/United States
GR  - NS10259/NS/NINDS NIH HHS/United States
GR  - NS17814/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Catecholamines)
RN  - 0 (Intermediate Filament Proteins)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Catecholamines/metabolism
MH  - Cytoskeleton/*metabolism
MH  - Ganglia, Spinal/*embryology
MH  - Intermediate Filament Proteins/metabolism
MH  - Rats
MH  - Trigeminal Ganglion/*embryology
MH  - Trigeminal Nerve/*embryology
MH  - Tyrosine 3-Monooxygenase/*metabolism
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 0012-1606(84)90116-7 [pii]
AID - 10.1016/0012-1606(84)90116-7 [doi]
PST - ppublish
SO  - Dev Biol. 1984 Jan;101(1):51-60. doi: 10.1016/0012-1606(84)90116-7.