PMID- 6141503
OWN - NLM
STAT- MEDLINE
DCOM- 19840302
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 33 Suppl 1
DP  - 1983
TI  - Ontogeny of opioid and related peptides in the rat cns and pituitary: an 
      immunocytochemical study.
PG  - 61-4
AB  - The development of proopiomelanocortin (POMC) derived peptides was compared to 
      that of leucine-enkephalin ([Leu]ENK) and dynorphin A (DYN-A) immunoreactivity 
      (i.r.) in the rat CNS and pituitary gland. POMC i.r. appeared first in 
      hypothalamic neurons on embryonic day E12, in pituitary anterior lobe (AL) cells 
      on E15, in pituitary intermediate lobe (IL) cells on E16, and in perikarya of the 
      nucleus tractus solitarius on E17. In the fetal stages (E19-22), all POMC systems 
      appeared adult-like; however, peak i.r. occurred between postnatal days P21-28. 
      The development of alpha-MSH (a-MSH) i.r. was dissimilar to that of other POMC 
      peptides including beta-endorphin (B-End). In contrast, both [Leu]ENK and DYN-A 
      i.r. appeared in later embryonic stages (E16-17), and their maturation lagged 
      behind that of POMC peptides. Peak i.r. for these latter peptides also occurred 
      between P21-28.
FAU - Khachaturian, H
AU  - Khachaturian H
FAU - Alessi, N E
AU  - Alessi NE
FAU - Munfakh, N
AU  - Munfakh N
FAU - Watson, S J
AU  - Watson SJ
LA  - eng
GR  - MH15794/MH/NIMH NIH HHS/United States
GR  - MH36851/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Endorphins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Pituitary Hormones, Anterior)
RN  - 0 (Protein Precursors)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 74913-18-1 (Dynorphins)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Brain/*embryology/growth & development
MH  - Dynorphins
MH  - Embryo, Mammalian
MH  - Endorphins/*analysis
MH  - Enkephalin, Leucine/analysis
MH  - Female
MH  - Peptide Fragments/analysis
MH  - Pituitary Gland/*embryology/growth & development
MH  - Pituitary Hormones, Anterior/*analysis
MH  - Pregnancy
MH  - Pro-Opiomelanocortin
MH  - Protein Precursors/*analysis
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 0024-3205(83)90444-7 [pii]
AID - 10.1016/0024-3205(83)90444-7 [doi]
PST - ppublish
SO  - Life Sci. 1983;33 Suppl 1:61-4. doi: 10.1016/0024-3205(83)90444-7.