PMID- 6142828
OWN - NLM
STAT- MEDLINE
DCOM- 19840511
LR  - 20190722
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 84
IP  - 1
DP  - 1984 Apr
TI  - Amino acid neurotransmission between fimbria-fornix fibers and neurons in the 
      lateral septum of the rat: a microiontophoretic study.
PG  - 126-39
AB  - We investigated the nature of the excitatory amino acid and the type of amino 
      acid receptor involved in the projection of fimbria-fornix (fi-fx) fibers on 
      neurons in the lateral septal complex (LSC) of the rat. It appeared that neurons 
      which were strongly orthodromically activated (SOA) by stimulation of fi-fx 
      fibers were excited by glutamate (GLU) and aspartate (ASP) at much lower ejecting 
      currents than neurons which were only weakly orthodromically excited. In 
      addition, GLU was a stronger agent than ASP, particularly in SOA septal cells. 
      Two amino acid antagonists tested, glutamic acid diethylester (GDEE) and 
      2-amino-5-phosphonovaleric acid (2-APV), selectively antagonized responses to the 
      amino acid agonists quisqualate (QUIS) and N-methyl-D-aspartate (NMDA), 
      respectively. They also depressed GLU- and ASP-induced responses, although in 
      that case the antagonists frequently had to be expelled with currents higher than 
      those needed to block QUIS- and NMDA-evoked excitations. Furthermore, GDEE 
      frequently antagonized GLU-induced responses better than ASP-evoked excitations, 
      whereas 2-APV often blocked responses to ASP more effectively than those to GLU. 
      It was observed that GDEE, ejected with currents that blocked responses to QUIS 
      reversibly, decreased the number of synaptic responses induced in SOA cells by 
      fi-fx stimuli. Synaptically induced excitation in these neurons was consistently 
      unaffected by 2-APV, even when the antagonist was expelled with high currents. 
      According to these results, LSC neurons, in particular the SOA neurons, are more 
      readily activated by GLU than by ASP. Monosynaptic excitations elicited in SOA 
      septal cells by fi-fx stimuli appear to be predominantly if not exclusively 
      mediated by QUIS receptors. There are indications that GLU-induced responses in 
      the LSC neurons are presumably mediated by the QUIS receptors. From these data it 
      may be inferred that GLU rather than ASP is the transmitter involved in the 
      projection of fi-fx fibers on LSC neurons.
FAU - Joels, M
AU  - Joels M
FAU - Urban, I J
AU  - Urban IJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Amino Acids)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Glutamates)
RN  - 0 (Oxadiazoles)
RN  - 0 (Receptors, Amino Acid)
RN  - 0 (Receptors, Cell Surface)
RN  - 16450-41-2 (glutamic acid diethyl ester)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate
MH  - Amino Acids/metabolism/*physiology
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/antagonists & 
      inhibitors/metabolism/physiology
MH  - Excitatory Amino Acid Antagonists
MH  - Glutamates/pharmacology/physiology
MH  - Hippocampus/*physiology
MH  - Iontophoresis
MH  - Male
MH  - N-Methylaspartate
MH  - Nerve Fibers/physiology
MH  - Neural Pathways/physiology
MH  - Neuromuscular Junction/*physiology
MH  - Oxadiazoles/metabolism
MH  - Quisqualic Acid
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Amino Acid
MH  - Receptors, Cell Surface/metabolism
MH  - Septal Nuclei/*physiology
MH  - *Synaptic Transmission
MH  - Valine/analogs & derivatives/pharmacology
EDAT- 1984/04/01 00:00
MHDA- 1984/04/01 00:01
CRDT- 1984/04/01 00:00
PHST- 1984/04/01 00:00 [pubmed]
PHST- 1984/04/01 00:01 [medline]
PHST- 1984/04/01 00:00 [entrez]
AID - 0014-4886(84)90010-4 [pii]
AID - 10.1016/0014-4886(84)90010-4 [doi]
PST - ppublish
SO  - Exp Neurol. 1984 Apr;84(1):126-39. doi: 10.1016/0014-4886(84)90010-4.