PMID- 6143729
OWN - NLM
STAT- MEDLINE
DCOM- 19840613
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 44
IP  - 2
DP  - 1984 May
TI  - Effect of lodoxamide on the secretory response induced by Escherichia coli and 
      Vibrio cholerae enterotoxins in infant mice.
PG  - 406-8
AB  - The effect of lodoxamide tromethamine, a calcium antagonist, on intestinal fluid 
      accumulation induced by Escherichia coli heat-stable (ST) and Vibrio cholerae 
      (CT) enterotoxins in infant mice was investigated. The simultaneous 
      administration of lodoxamide with ST or CT enterotoxin resulted in a significant 
      (P less than 0.01) inhibition of the intestinal fluid response. A minimum 
      concentration of 10(-7) or 10(-8)M lodoxamide caused an inhibition (P less than 
      0.01) of the ST- or CT-mediated fluid response, respectively. Treatment of infant 
      mice with buffer or drug alone did not result in fluid accumulation. A 
      significant inhibition of ST and CT enterotoxic activities was also observed when 
      lodoxamide was administered 30 min before (P less than 0.02) or 30 min after (P 
      less than 0.01) toxin challenge. These data suggest that calcium may be important 
      in the ST- or CT-mediated induction of fluid accumulation. Further studies on the 
      potential use of lodoxamide tromethamine in both the prophylaxis and treatment of 
      diarrheal disease appear warranted.
FAU - Knoop, F C
AU  - Knoop FC
FAU - Thomas, D D
AU  - Thomas DD
LA  - eng
GR  - RR05390/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Amino Acids)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Nitriles)
RN  - 0 (heat stable toxin (E coli))
RN  - 0 (stN protein, Vibrio cholerae)
RN  - 023C2WHX2V (Tromethamine)
RN  - 50LV9A548L (lodoxamide tromethamine)
RN  - QU60N5OPLG (Oxamic Acid)
SB  - IM
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Bacterial Toxins/isolation & purification/*toxicity
MH  - Biological Assay
MH  - Enterotoxins/isolation & purification/*toxicity
MH  - Escherichia coli Proteins
MH  - Gastric Mucosa/drug effects/*metabolism
MH  - Histamine H1 Antagonists/*pharmacology
MH  - Intestinal Mucosa/drug effects/*metabolism
MH  - Mice
MH  - Nitriles
MH  - Oxamic Acid/analogs & derivatives/*pharmacology
MH  - Tromethamine/*analogs & derivatives/pharmacology
PMC - PMC263533
EDAT- 1984/05/01 00:00
MHDA- 1984/05/01 00:01
PMCR- 1984/05/01
CRDT- 1984/05/01 00:00
PHST- 1984/05/01 00:00 [pubmed]
PHST- 1984/05/01 00:01 [medline]
PHST- 1984/05/01 00:00 [entrez]
PHST- 1984/05/01 00:00 [pmc-release]
AID - 10.1128/iai.44.2.406-408.1984 [doi]
PST - ppublish
SO  - Infect Immun. 1984 May;44(2):406-8. doi: 10.1128/iai.44.2.406-408.1984.