PMID- 6144574
OWN - NLM
STAT- MEDLINE
DCOM- 19840725
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 171
IP  - 2
DP  - 1984 Jun 11
TI  - The competitive inhibition of tissue transglutaminase by 
      alpha-difluoromethylornithine.
PG  - 221-6
AB  - The transglutaminase-mediated insertion of putrescine into casein was inhibited 
      competitively by alpha-difluoromethylornithine (alpha-DFMO), an enzyme-activated 
      irreversible inhibitor of ornithine decarboxylase. Preincubation of the amine 
      acceptor (casein) or the enzyme itself with the inhibitor did not affect enzyme 
      activity. Alpha-DFMO is a poorer substrate for transglutaminase (Km = 2.10 mM) 
      than putrescine (Km = 0.17 mM). The inhibitory effect was also found with 
      fibronectin as amine acceptor.
FAU - Delcros, J G
AU  - Delcros JG
FAU - Roch, A M
AU  - Roch AM
FAU - Quash, G
AU  - Quash G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Caseins)
RN  - E524N2IXA3 (Ornithine)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - V10TVZ52E4 (Putrescine)
RN  - ZQN1G5V6SR (Eflornithine)
SB  - IM
MH  - Acyltransferases/*antagonists & inhibitors
MH  - Animals
MH  - Caseins/metabolism
MH  - Eflornithine
MH  - Guinea Pigs
MH  - Kinetics
MH  - Liver/enzymology
MH  - Ornithine/*analogs & derivatives/metabolism/pharmacology
MH  - Putrescine/metabolism
MH  - Transglutaminases
EDAT- 1984/06/11 00:00
MHDA- 1984/06/11 00:01
CRDT- 1984/06/11 00:00
PHST- 1984/06/11 00:00 [pubmed]
PHST- 1984/06/11 00:01 [medline]
PHST- 1984/06/11 00:00 [entrez]
AID - 0014-5793(84)80492-5 [pii]
AID - 10.1016/0014-5793(84)80492-5 [doi]
PST - ppublish
SO  - FEBS Lett. 1984 Jun 11;171(2):221-6. doi: 10.1016/0014-5793(84)80492-5.