PMID- 6148317
OWN - NLM
STAT- MEDLINE
DCOM- 19841113
LR  - 20121115
IS  - 0020-725X (Print)
IS  - 0020-725X (Linking)
VI  - 29
IP  - 2
DP  - 1984
TI  - Subcutaneous and intrabursal administration of an LRH agonist to the pregnant 
      hemicastrated rat during preimplantation.
PG  - 122-8
AB  - A single injection of the LRH agonist, Wy-40,972, under the right ovarian bursa 
      (IB) on any individual day (D) 1-7 in the pregnant rat increased still further 
      the compensatory ovarian weight gain produced by hemicastration (HC) alone. 
      Conversely, a single subcutaneous (sc) injection during the same period abolished 
      the compensatory hypertrophy and reduced the weight of the remaining ovary to 
      that of the ovary of the intact rat and below. The single sc or IB injections of 
      Wy-40,972 were most effective in delaying implantation when administered on D3-4 
      or 4, respectively. Subcutaneous administration on D5, 6, or 7 produced an 
      antifertility effect, whereas IB administration on any of these 3 days failed to 
      modify the pregnancy. These data demonstrate that the LRH agonist, Wy-40,972, 
      acts directly on the ovary with regard to both weight increase and delay of 
      blastocyst implantation. The results are discussed in relation to hormonal 
      requirements for implantation and desensitization of the ovary.
FAU - Jones, R C
AU  - Jones RC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Int J Fertil
JT  - International journal of fertility
JID - 0374717
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - G137G5DMW7 (lutrelin acetate)
SB  - IM
MH  - Animals
MH  - Castration
MH  - Embryo Implantation/drug effects
MH  - *Embryonic Development
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology
MH  - Organ Size/drug effects
MH  - Ovary/*drug effects/physiology
MH  - Pregnancy
MH  - Rats
MH  - Uterus/drug effects
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
PST - ppublish
SO  - Int J Fertil. 1984;29(2):122-8.