PMID- 6150093
OWN - NLM
STAT- MEDLINE
DCOM- 19850110
LR  - 20190710
IS  - 0022-3573 (Print)
IS  - 0022-3573 (Linking)
VI  - 36
IP  - 10
DP  - 1984 Oct
TI  - Central and peripheral inhibition of gastrointestinal transit in rats: narcotics 
      differ substantially by acting at either or both levels.
PG  - 699-701
AB  - The roles of local intestinal and centrally mediated opiate-specific mechanisms 
      underlying gastrointestinal transit inhibiton by five typical narcotic analgesics 
      were assessed by the rat charcoal meal test. The doses (mg kg-1 s.c.) reducing 
      the progression of charcoal to 50% of drug-free controls in 5 min (ID50) were 
      approximately 1 for morphine and methadone, 0.5 and 40 for diamorphine and 
      pethidine (all given 25 min before charcoal) and 0.001 for etorphine (10 min 
      before charcoal). The delay in test meal travel caused by these ID50 doses was 
      completely prevented by i.p. naloxone. Intracerebroventricular (i.c.v.) naloxone 
      fully antagonized pethidine and etorphine but had no effect on morphine. 
      Morphine, but either pethidine nor etorphine, was antagonized by i.p. N-methyl 
      naloxone (a peripheral antagonist). Diamorphine and methadone were partially 
      antagonized by i.c.v. naloxone or i.p. N-methyl naloxone.
FAU - Peracchia, F
AU  - Peracchia F
FAU - Bianchi, G
AU  - Bianchi G
FAU - Fiocchi, R
AU  - Fiocchi R
FAU - Petrillo, P
AU  - Petrillo P
FAU - Tavani, A
AU  - Tavani A
FAU - Manara, L
AU  - Manara L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Analgesics, Opioid)
RN  - 36B82AMQ7N (Naloxone)
RN  - 42M2Y6NU9O (Etorphine)
RN  - 70D95007SX (Heroin)
RN  - 76I7G6D29C (Morphine)
RN  - 9E338QE28F (Meperidine)
SB  - IM
MH  - Analgesics, Opioid/administration & dosage/*pharmacology
MH  - Animals
MH  - Etorphine/pharmacology
MH  - Gastrointestinal Motility/*drug effects
MH  - Heroin/pharmacology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Meperidine/pharmacology
MH  - Morphine/pharmacology
MH  - Naloxone/pharmacology
MH  - Rats
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 10.1111/j.2042-7158.1984.tb04850.x [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 1984 Oct;36(10):699-701. doi: 
      10.1111/j.2042-7158.1984.tb04850.x.