PMID- 6152873
OWN - NLM
STAT- MEDLINE
DCOM- 19880610
LR  - 20191023
IS  - 0742-0528 (Print)
IS  - 0742-0528 (Linking)
VI  - 1
IP  - 1
DP  - 1984
TI  - Role of autonomic nervous system in the time-dependent hyperglycemia induced by 
      intracranial injection of D-mannitol and D-glucose.
PG  - 27-35
AB  - Intracranial injection of D-mannitol (MA) or D-glucose (GL) caused photoperiodic 
      hyperglycemia in rats; MA injection elicited hyperglycemia only in the light 
      period, while GL injection induced it only in the dark period. To elucidate the 
      mechanisms of these hyperglycemias, we examined the effect of the autonomic 
      nervous system on them in rats under the L:D (12:12) condition. Propranolol, a 
      beta-adrenergic blocker, and hexamethonium, a ganglion blocker, effectively 
      inhibited hyperglycemia induced in either the light (MA) or dark (GL) period. In 
      contrast, phenoxybenzamine, an alpha-adrenergic blocker, and atropine, a 
      cholinergic blocker, inhibited hyperglycemia induced in the light period (MA), 
      but not that induced in the dark period (GL). These findings suggest that alpha 
      and beta-adrenergic and cholinergic mechanisms are involved in the hyperglycemia 
      induced by MA in the light period, while only the beta-adrenergic mechanism is 
      involved in the hyperglycemia induced by GL in the dark period.
FAU - Yamamoto, H
AU  - Yamamoto H
AD  - Institute for Protein Research, Osaka University, Japan.
FAU - Nagai, K
AU  - Nagai K
FAU - Nakagawa, H
AU  - Nakagawa H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
RN  - 0 (Hexamethonium Compounds)
RN  - 0TTZ664R7Z (Phenoxybenzamine)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 3OWL53L36A (Mannitol)
RN  - 7C0697DR9I (Atropine)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Autonomic Nervous System/drug effects/*physiopathology
MH  - *Circadian Rhythm
MH  - Darkness
MH  - Glucose/administration & dosage/*toxicity
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Hyperglycemia/chemically induced/*physiopathology/prevention & control
MH  - Injections, Intraventricular
MH  - Light
MH  - Male
MH  - Mannitol/administration & dosage/*toxicity
MH  - Phenoxybenzamine/pharmacology
MH  - Propranolol/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.3109/07420528409059115 [doi]
PST - ppublish
SO  - Chronobiol Int. 1984;1(1):27-35. doi: 10.3109/07420528409059115.