PMID- 6154156 OWN - NLM STAT- MEDLINE DCOM- 19800625 LR - 20190817 IS - 0047-1828 (Print) IS - 0047-1828 (Linking) VI - 44 IP - 2 DP - 1980 Feb TI - Successful control of refractory ventricular premature beat with an estrogen-progesterone compound. PG - 146-50 AB - Drug resistant ventricular premature contractions (VPCs) in a 35-yr-old woman were successfully controlled with a contraceptive agent containing estrogen-progesterone. The VPCs in this patient always showed an R on T phenomenon resulting in occasional short run of ventricular tachycardia. Apart from the VPCs, her ECG exhibited no abnormalities. The family history revealed 9 instances of sudden unexpected death over 3 generations. The findings of myocardial biopsy of the right ventricular endocardium were characteristic of cardiomyopathy. This report discusses the possibility that a contraceptive agent successfully suppressed VPCs in a particular woman who showed a close relation between a certain period of her menstrual cycle and the occurrence of VPCs. FAU - Ishikawa, K AU - Ishikawa K FAU - Yanagisawa, A AU - Yanagisawa A FAU - Ishikawa, M AU - Ishikawa M FAU - Tohno, T AU - Tohno T LA - eng PT - Case Reports PT - Journal Article PL - Japan TA - Jpn Circ J JT - Japanese circulation journal JID - 7806868 RN - 0 (Contraceptives, Oral) RN - 0 (Contraceptives, Oral, Hormonal) RN - 0 (Estrogens) RN - 4G7DS2Q64Y (Progesterone) SB - IM MH - Adult MH - Cardiac Complexes, Premature/*drug therapy/genetics/physiopathology MH - Cardiomyopathies/complications/pathology MH - Contraceptives, Oral/*therapeutic use MH - Contraceptives, Oral, Hormonal/*therapeutic use MH - Death, Sudden MH - Electrocardiography MH - Estrogens/*administration & dosage MH - Female MH - Humans MH - Menstruation MH - Myocardium/pathology MH - Progesterone/*administration & dosage EDAT- 1980/02/01 00:00 MHDA- 1980/02/01 00:01 CRDT- 1980/02/01 00:00 PHST- 1980/02/01 00:00 [pubmed] PHST- 1980/02/01 00:01 [medline] PHST- 1980/02/01 00:00 [entrez] AID - 10.1253/jcj.44.146 [doi] PST - ppublish SO - Jpn Circ J. 1980 Feb;44(2):146-50. doi: 10.1253/jcj.44.146.