PMID- 6159103
OWN - NLM
STAT- MEDLINE
DCOM- 19810116
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 22
IP  - 1 Pt 1
DP  - 1980 Nov
TI  - A model of cell activation and desensitization by surface immunoglobin: the case 
      of histamine release from human basophils.
PG  - 59-67
AB  - We present a model for the control of immunoglobulin E (IgE)-mediated histamine 
      release from human basophils. We suggest that there is a calcium gating factor 
      which interacts with crosslinked IgE to form a short-lived open calcium channel. 
      After formation of the channel the activated gating factor rapidly decays to an 
      inactive form. It is the loss of the active gating factor which causes the 
      basophil to desensitize nonspecifically. We propose that the crosslinked IgE 
      molecules are deactivated by a mechanism, such as endocytosis or shedding, which 
      is independent of the mechanism which inactivates the calcium gating factor. This 
      loss of functional IgE leads to specific desensitization. The mathematical 
      formulation of the model explains the relationship of specific and nonspecific 
      desensitization to the amount of specific IgE on the basophil surface; explains 
      why there are two types of antigen excess inhibition; explains the relationship 
      between antigen excess inhibition and desensitization; explains why, for a fixed 
      antigen concentration, increasing the concentration of cell surface IgE increases 
      histamine release until an optimal concentration is reached, then decreases 
      histamine release; predicts the effects that changing the external calcium will 
      have on the dose response curve; and predicts that increasing the amount of 
      specific IgE on the cell surface will cause the dose response curve to undergo a 
      transition from a curve with a single maximum to a curve with two maxima.
FAU - Dembo, M
AU  - Dembo M
FAU - Goldstein, B
AU  - Goldstein B
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Ion Channels)
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - 0 (Receptors, Fc)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Basophils/*immunology
MH  - Calcium/metabolism
MH  - *Desensitization, Immunologic
MH  - *Histamine Release
MH  - Humans
MH  - Immunoglobulin E/physiology
MH  - Ion Channels
MH  - Mathematics
MH  - *Models, Biological
MH  - Receptors, Antigen, B-Cell/*physiology
MH  - Receptors, Fc/metabolism
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 0092-8674(80)90154-3 [pii]
AID - 10.1016/0092-8674(80)90154-3 [doi]
PST - ppublish
SO  - Cell. 1980 Nov;22(1 Pt 1):59-67. doi: 10.1016/0092-8674(80)90154-3.