PMID- 6160766
OWN - NLM
STAT- MEDLINE
DCOM- 19810224
LR  - 20190627
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 69
IP  - 6
DP  - 1980 Dec
TI  - Anaphylactic reactions following infusion of factor VIII in a patient with 
      classic hemophilia.
PG  - 953-7
AB  - A 28 year old white man with hemophilia A had, for several years, been 
      successfully maintained on a home care program utilizing self-administration of 
      factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. 
      An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by 
      (1) the release of histamine from the patient's basophils in vitro upon challenge 
      with several different lots of factor VIII concentrate; (2) immediate cutaneous 
      response to commercial factor VIII, factor IX and cryoprecipitate; and (3) 
      measurement of IgE antibodies against a commercial factor VIII preparation. A 
      subsequent life-threatening hemorrhage required cautious infusion of another 
      commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic 
      drugs and attempted desensitization, a moderately severe anaphylactic reaction 
      was observed.
FAU - Helmer, R E 3rd
AU  - Helmer RE 3rd
FAU - Alperin, J B
AU  - Alperin JB
FAU - Yunginger, J W
AU  - Yunginger JW
FAU - Grant, J A
AU  - Grant JA
LA  - eng
GR  - AI 00107/AI/NIAID NIH HHS/United States
GR  - AI 00110/AI/NIAID NIH HHS/United States
GR  - RR-73/RR/NCRR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9001-27-8 (Factor VIII)
SB  - IM
MH  - Adult
MH  - Anaphylaxis/*immunology
MH  - Basophils/immunology
MH  - Factor VIII/*immunology/therapeutic use
MH  - Hemophilia A/immunology/*therapy
MH  - Histamine Release
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/immunology
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
AID - S0002-9343(80)80026-X [pii]
AID - 10.1016/s0002-9343(80)80026-x [doi]
PST - ppublish
SO  - Am J Med. 1980 Dec;69(6):953-7. doi: 10.1016/s0002-9343(80)80026-x.