PMID- 6165799
OWN - NLM
STAT- MEDLINE
DCOM- 19810827
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 153
IP  - 2
DP  - 1981 Feb 1
TI  - Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted 
      anti-idiotypic suppressor factor from efferent suppressor T cells.
PG  - 450-63
AB  - Azobenzenearsonate (ABA)-specific T cell-derived suppressor factor (TsF1) from 
      A/J mice was used to induced second-order suppressor T cells (Ts2). Comparison of 
      suppressor T cells induced by antigen (Ts1) with Ts2 induced by TsF1 revealed 
      that Ts1 were afferent suppressors active only when given at the time of antigen 
      priming, and not thereafter, whereas Ts2 could act when transferred at any time 
      up to 1 d before antigen challenge for a delayed-type hypersensitivity response. 
      This was true even when the recipient could be shown to be fully immune before 
      transfer of Ts2, thus defining these cells as efferent suppressors. The 
      anti-idiotypic specificity of the Ts2 was demonstrated by the ability of Ts to 
      bind to idiotype (cross-reactive idiotype [CRI])-coated Petri dishes. A soluble 
      extract from Ts2 (TsF2) was also capable of mediating efferent suppression that 
      was functionally antigen- (ABA) specific. Comparison of TsF1 with this new 
      factor, TsF2, revealed that both lack Ig-constant-region determinants, possess 
      H-2-coded determinants, and show specific binding (to ABA and to CRI+-Ig, 
      respectively). TsF1 acts in strains that differ with respect to H-2 and 
      background genes, whereas TsF2 shows H-2- and non-H-2-linked genetic 
      restrictions. This existence of H-2 restriction of TsF2 activity suggests that 
      the apparent discrepancies in studies of H-2 restriction of TsF may be a result 
      of the analysis of two separate classes of TsF, only one of which shows 
      genetically restricted activity, thus unifying several models of suppressor cell 
      activity.
FAU - Dietz, M H
AU  - Dietz MH
FAU - Sy, M S
AU  - Sy MS
FAU - Benacerraf, B
AU  - Benacerraf B
FAU - Nisonoff, A
AU  - Nisonoff A
FAU - Greene, M I
AU  - Greene MI
FAU - Germain, R N
AU  - Germain RN
LA  - eng
GR  - AI-12907/AI/NIAID NIH HHS/United States
GR  - AI-14732/AI/NIAID NIH HHS/United States
GR  - AI-16396/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Epitopes)
RN  - 0 (H-2 Antigens)
RN  - 0 (Immunoglobulin Idiotypes)
RN  - 0 (Lymphokines)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Suppressor Factors, Immunologic)
RN  - 7334-23-8 (p-Azobenzenearsonate)
SB  - IM
MH  - Animals
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Cross Reactions
MH  - Epitopes
MH  - *H-2 Antigens
MH  - Hypersensitivity, Delayed/immunology
MH  - *Immunoglobulin Idiotypes
MH  - Lymphokines/*biosynthesis
MH  - Mice
MH  - Mice, Inbred A
MH  - Protein Biosynthesis
MH  - *Receptors, Immunologic
MH  - Suppressor Factors, Immunologic
MH  - Time Factors
MH  - p-Azobenzenearsonate/immunology
PMC - PMC2186080
EDAT- 1981/02/01 00:00
MHDA- 1981/02/01 00:01
PMCR- 1981/08/01
CRDT- 1981/02/01 00:00
PHST- 1981/02/01 00:00 [pubmed]
PHST- 1981/02/01 00:01 [medline]
PHST- 1981/02/01 00:00 [entrez]
PHST- 1981/08/01 00:00 [pmc-release]
AID - 81217271 [pii]
AID - 10.1084/jem.153.2.450 [doi]
PST - ppublish
SO  - J Exp Med. 1981 Feb 1;153(2):450-63. doi: 10.1084/jem.153.2.450.