PMID- 6169263
OWN - NLM
STAT- MEDLINE
DCOM- 19811118
LR  - 20190825
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 11
IP  - 4
DP  - 1981 Jul
TI  - In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634.
PG  - 345-51
AB  - The effects of Ro 21-7634 and disodium cromoglycate (cromoglycate) on the in 
      vitro release of mediators of anaphylaxis from rat peritoneal cells and guinea 
      pig lung tissue were compared. Ro 21-7634 was 25 fold more potent than 
      cromoglycate as an inhibitor of antigen-induced histamine release from passively 
      sensitized (IgE) rat peritoneal cells. Ro 21-7634 was also the more potent 
      inhibitor of both compound 48/80- and concanavalin A-induced histamine release 
      from rat peritoneal cells. The two drugs shared the common properties of 
      producing the same maximal level of inhibition in each of the above releasing 
      systems and exhibiting a time and concentration dependent loss of inhibitory 
      activity when added to the cells prior to the releasing agent. Neither drug 
      inhibited ionophore A23187-or ionophore X537A-induced histamine release from 
      these cells. Ro 21-7634 inhibited antigen-induced (IgG1) histamine and SRS-A 
      release from actively sensitized guinea pig lung fragments, whereas cromoglycate 
      did not. The results indicate that Ro 21-7634 and cromoglycate act through a 
      common mechanism to inhibit allergic mediator release and that Ro 21-7634 is the 
      more potent inhibitor.
FAU - Welton, A F
AU  - Welton AF
FAU - Hope, W C
AU  - Hope WC
FAU - Crowley, H J
AU  - Crowley HJ
FAU - Salvador, R A
AU  - Salvador RA
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Histamine Antagonists)
RN  - 0 (SRS-A)
RN  - 11028-71-0 (Concanavalin A)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - Q2WXR1I0PK (Cromolyn Sodium)
SB  - IM
MH  - Animals
MH  - Concanavalin A/antagonists & inhibitors
MH  - Cromolyn Sodium/*pharmacology
MH  - *Histamine Antagonists
MH  - Histamine Release/drug effects
MH  - Lung/metabolism
MH  - Male
MH  - Mast Cells/drug effects
MH  - Rats
MH  - SRS-A/*antagonists & inhibitors
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1981/07/01 00:00
MHDA- 1981/07/01 00:01
CRDT- 1981/07/01 00:00
PHST- 1981/07/01 00:00 [pubmed]
PHST- 1981/07/01 00:01 [medline]
PHST- 1981/07/01 00:00 [entrez]
AID - 10.1007/BF01982470 [doi]
PST - ppublish
SO  - Agents Actions. 1981 Jul;11(4):345-51. doi: 10.1007/BF01982470.