PMID- 6169426
OWN - NLM
STAT- MEDLINE
DCOM- 19811215
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 4
IP  - 1
DP  - 1981 Aug
TI  - Familial acute myelogenous leukemia associated with RNA virus and polymorphism of 
      1qh+.
PG  - 23-30
AB  - In order to investigate the genetic background of leukemogenesis of two brothers 
      with acute myelogenous leukemia (AML), they and their family members were studied 
      genetically, immunologically, virologically, and cytogenetically. Their parents 
      were first cousins once removed and had the same or a very close type of human 
      leukocyte antigen (HLA) and blood groups. In all five non-leukemic family members 
      the immunoglobulin G (IgG) level was elevated, and in two healthy siblings the 
      IgM level was beyond the normal range. The RNA reverse transcriptase activity in 
      serum of the younger brother (Case 2) with AML was elevated. A cytogenetic study 
      of the family revealed polymorphism of 1qh+. Based on these findings, we discuss 
      the genetic and environmental factors of familial leukemia.
FAU - Sadamori, N
AU  - Sadamori N
FAU - Nonaka, H
AU  - Nonaka H
FAU - Ichimaru, M
AU  - Ichimaru M
FAU - Igarashi, H
AU  - Igarashi H
FAU - Hirota, M
AU  - Hirota M
FAU - Sawada, H
AU  - Sawada H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (RNA, Viral)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
SB  - IM
MH  - Adult
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/blood/*genetics/immunology/microbiology
MH  - Male
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - RNA Viruses
MH  - RNA, Viral/analysis
MH  - RNA-Directed DNA Polymerase/analysis
MH  - Virus Diseases/*complications
EDAT- 1981/08/01 00:00
MHDA- 1981/08/01 00:01
CRDT- 1981/08/01 00:00
PHST- 1981/08/01 00:00 [pubmed]
PHST- 1981/08/01 00:01 [medline]
PHST- 1981/08/01 00:00 [entrez]
AID - 0165-4608(81)90004-2 [pii]
AID - 10.1016/0165-4608(81)90004-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1981 Aug;4(1):23-30. doi: 10.1016/0165-4608(81)90004-2.