PMID- 6170156
OWN - NLM
STAT- MEDLINE
DCOM- 19811221
LR  - 20181130
IS  - 0300-9858 (Print)
IS  - 0300-9858 (Linking)
VI  - 18
IP  - 6
DP  - 1981 Nov
TI  - Leukocyte-dependent platelet vasoactive amine release and immune complex 
      deposition in African swine fever.
PG  - 813-26
AB  - Fifteen pigs were inoculated with African swine fever virus in a study of the 
      pathogenesis of the disease. All pigs surviving the first two weeks developed 
      high circulating antibody titers against African swine fever virus and persistent 
      viremia. Hemolytic complement levels declined to 50 to 70 hemolytic complement 50 
      (CH50) units/ml from mean preinoculation levels of 120 CH50 units/ml. Immune 
      deposits consisting of African swine fever antigen, host immunoglobulin G, and 
      native C3 were found in the glomeruli of surviving pigs. All pigs surviving two 
      weeks after inoculation developed leukocyte-bound antibody functionally 
      characteristic of immunoglobulin E (IgE). Antigen-specific degranulation of 
      antibody-coated leukocytes produced secondary platelet aggregation and vasoactive 
      amine release. The results suggest that the IgE-basophil-platelet loop acting via 
      amplification by leukocyte-derived platelet-activating factor participates in the 
      immune complex deposition process in African swine fever.
FAU - Slauson, D O
AU  - Slauson DO
FAU - Sanchez-Vizcaino, J M
AU  - Sanchez-Vizcaino JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Epitopes)
RN  - 0 (Lysophosphatidylcholines)
RN  - 0 (Platelet Activating Factor)
RN  - 333DO1RDJY (Serotonin)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - African Swine Fever/etiology/*immunology/pathology
MH  - Animals
MH  - Antibodies, Viral/analysis
MH  - Antigen-Antibody Complex/*metabolism
MH  - Blood Platelets/*metabolism
MH  - Complement System Proteins/analysis
MH  - Epitopes
MH  - Leukocytes/*physiology
MH  - Lysophosphatidylcholines/physiology
MH  - Platelet Activating Factor
MH  - Platelet Aggregation
MH  - Serotonin/*metabolism
MH  - Swine
EDAT- 1981/11/01 00:00
MHDA- 1981/11/01 00:01
CRDT- 1981/11/01 00:00
PHST- 1981/11/01 00:00 [pubmed]
PHST- 1981/11/01 00:01 [medline]
PHST- 1981/11/01 00:00 [entrez]
AID - 10.1177/030098588101800611 [doi]
PST - ppublish
SO  - Vet Pathol. 1981 Nov;18(6):813-26. doi: 10.1177/030098588101800611.