PMID- 6175837
OWN - NLM
STAT- MEDLINE
DCOM- 19820621
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 4 Suppl 1
DP  - 1982
TI  - Clinical and hemodynamic improvement of congestive heart failure by long-term 
      vasodilator therapy with postjunctional alpha 1-adrenoceptor blockade.
PG  - S181-6
AB  - Eleven of 12 patients with severe congestive heart failure who were pretreated 
      with diuretics and digitalis benefited from long-term therapy with prazosin which 
      was titrated to the individual's maximally tolerated dose. Nine of the 11 
      patients improved their functional state by one (n = 4) or two (n = 5) New York 
      Heart Association (NYHA) classes. Within 4 weeks the stroke volume index 
      increased from 23 +/- 10 to 29 +/- 9 SD (ml/beat/m2) while pulmonary capillary 
      pressure decreased from 29 +/- 8 +/- 9 mm Hg (p less than 0.05 for both) and 
      peripheral vascular resistance fell from 2,245 +/- 792 to 1,603 +/- 355 dyn/s 
      cm-5 (p less than 0.01). Hemodynamics results were similar on the same regimen in 
      eight patients assessed for 6 months. Death of three patients (week 5 and week 
      17) was unrelated to prazosin therapy. Prazosin resulted in improved cardiac 
      performance during leg-up-tilt or supine ergometry. Increase in stroke volume 
      index was related to the fall in peripheral vascular resistance (r = -0.79, p 
      less than 0.01). Plasma adrenaline (301 +/- 480 pg/Ml), noradrenaline (1,312 +/- 
      1,382 pg/ml), and renin activity (22 +/- 30 ng/ml/h) were in the range observed 
      with pheochromocytoma; variables did not change on prazosin. This reflects an 
      important role of alpha-adrenoceptor-mediated vascular regulation in patients 
      with heart failure in whom long-term treatment with prazosin produces a sustained 
      and well-tolerated vasodilator effect without further rise in catecholamines and 
      renin.
FAU - Bertel, O
AU  - Bertel O
FAU - Buhler, F R
AU  - Buhler FR
FAU - Burkart, F
AU  - Burkart F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Vasodilator Agents)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/*therapeutic use
MH  - Aged
MH  - Epinephrine/blood
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Long-Term Care
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/blood
MH  - Physical Exertion
MH  - Renin/blood
MH  - Vasodilator Agents/*therapeutic use
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1097/00005344-198200041-00036 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1982;4 Suppl 1:S181-6. doi: 
      10.1097/00005344-198200041-00036.